Sarcoma Epidemiology and Etiology: Potential Environmental and Genetic Factors

Guy Lahat, Alexander Lazar, Dina Lev*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Sarcomas are a heterogeneous group of tumors that may have many etiologies. The incidence of histologic subtypes differs significantly between children and adults. The increase in incidence may be due to improved registry systems, diagnostic tools, and pathologic definitions. Environmental causes may contribute to increased incidence. Genetic alternations may play a role in sarcoma development. As a result of rapidly evolving genomic and proteomic technologies, increased knowledge of the oncogenic mechanisms underlying sarcomagenesis is being generated. Understanding the mechanisms involved in sarcomagenesis is rudimentary. Insight into the molecular basis of sarcoma inception, proliferation, and dissemination hopefully will lead to more effective therapies.

Original languageEnglish
Pages (from-to)451-481
Number of pages31
JournalSurgical Clinics of North America
Issue number3
StatePublished - Jun 2008
Externally publishedYes


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