Sarafotoxin receptors mediate phosphoinositide hydrolysis in various rat brain regions

Y. Kloog, I. Ambar, E. Kochva, Z. Wollberg, A. Bdolah, M. Sokolovsky

Research output: Contribution to journalArticlepeer-review

Abstract

Sarafotoxin-b, a potent snake vasoconstrictor peptide homologous to the mammalian endothelial vasoconstrictor endothelin, induces phosphoinositide (PI) hydrolysis in various brain regions of the rat. Sarafotoxin-b induced PI hydrolysis is largely independent of extracellular Ca2+ and is detected in all brain regions where toxin-binding sites are found. These results point to the existence of a hitherto undetected neuroreceptor associated with the PI cycle.

Original languageEnglish
Pages (from-to)387-390
Number of pages4
JournalFEBS Letters
Volume242
Issue number2
DOIs
StatePublished - 2 Jan 1989

Keywords

  • (Rat brain)
  • Endothelin
  • Phosphoinositide
  • Receptor
  • Sarafotoxin
  • Snake venom

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