Abstract
Sarafotoxin-b, a potent snake vasoconstrictor peptide homologous to the mammalian endothelial vasoconstrictor endothelin, induces phosphoinositide (PI) hydrolysis in various brain regions of the rat. Sarafotoxin-b induced PI hydrolysis is largely independent of extracellular Ca2+ and is detected in all brain regions where toxin-binding sites are found. These results point to the existence of a hitherto undetected neuroreceptor associated with the PI cycle.
Original language | English |
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Pages (from-to) | 387-390 |
Number of pages | 4 |
Journal | FEBS Letters |
Volume | 242 |
Issue number | 2 |
DOIs | |
State | Published - 2 Jan 1989 |
Keywords
- (Rat brain)
- Endothelin
- Phosphoinositide
- Receptor
- Sarafotoxin
- Snake venom