Sanctuary of hepatitis B virus in bone-marrow cells of patients undergoing liver transplantation

Y. Ilan, E. Galun, A. Nagler, Y. Baruch, N. Livni, R. Tur-Kaspa

Research output: Contribution to journalArticlepeer-review

Abstract

Hepatitis B virus (HBV) reinfection after liver transplantation is a major problem. HBV is mainly a hepatotrophic virus but replicates in many extrahepatic tissues. We present here two cases of infected patients who underwent liver transplantation. Both underwent bone marrow (BM) and liver biopsies after transplantation. Biopsy specimens were stained for hepatitis B surface antigen (HBsAg), and bone marrow aspirates and were separated for all subsets of cells. In both cases, HBV DNA analysis detected DNA in all BM fractions after transplantation, but HBV recurrence was found only in one case. We suggest that graft reinfection after liver transplantation may be caused by active replication of HBV in extrahepatic tissues and that BM cells are probably one of the major sanctuaries. The use of immunoprophylaxis based on BM-HBV studies is discussed.

Original languageEnglish
Pages (from-to)206-210
Number of pages5
JournalLiver Transplantation and Surgery
Volume2
Issue number3
DOIs
StatePublished - 1996
Externally publishedYes

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