Salivary flow-rate and composition in schizophrenic patients on clozapine: Subjective reports and laboratory data

Hanna Ben-Aryeh, T. Jungerman, R. Szargel, E. Klein, D. Laufer

Research output: Contribution to journalArticlepeer-review

Abstract

The extent of hypersalivation was evaluated in a group of 25 schizophrenic patients on clopazine. A high prevalence of the complaint was detected by a questionnaire; up to 80% of the patients complained of hypersalivation at night. Salivary flow-rate and composition was examined in 17 patients who agreed to participate and in a matched group of healthy controls. No significant differences were detected in composition or flow-rates of resting and stimulated saliva. The salivary flow-rates in the schizophrenic patients on clopazine did not correlate with the subjective complaint of hypersalivation. Because the severity and prevalence of the complaint was higher at night, a possibility of an altered circadian rhythm of salivation might be suggested in these patients.

Original languageEnglish
Pages (from-to)946-949
Number of pages4
JournalBiological Psychiatry
Volume39
Issue number11
DOIs
StatePublished - 1 Jun 1996
Externally publishedYes

Keywords

  • Saliva
  • clozapine
  • flow-rate and composition
  • hypersalivation
  • schizophrenic patients

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