Abstract
The extent of hypersalivation was evaluated in a group of 25 schizophrenic patients on clopazine. A high prevalence of the complaint was detected by a questionnaire; up to 80% of the patients complained of hypersalivation at night. Salivary flow-rate and composition was examined in 17 patients who agreed to participate and in a matched group of healthy controls. No significant differences were detected in composition or flow-rates of resting and stimulated saliva. The salivary flow-rates in the schizophrenic patients on clopazine did not correlate with the subjective complaint of hypersalivation. Because the severity and prevalence of the complaint was higher at night, a possibility of an altered circadian rhythm of salivation might be suggested in these patients.
Original language | English |
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Pages (from-to) | 946-949 |
Number of pages | 4 |
Journal | Biological Psychiatry |
Volume | 39 |
Issue number | 11 |
DOIs | |
State | Published - 1 Jun 1996 |
Externally published | Yes |
Keywords
- Saliva
- clozapine
- flow-rate and composition
- hypersalivation
- schizophrenic patients