TY - JOUR
T1 - Salarins D-J, seven new nitrogenous macrolides from the madagascar sponge Fascaplysinopsis sp.
AU - Bishara, Ashgan
AU - Rudi, Amira
AU - Aknin, Maurice
AU - Neumann, Drorit
AU - Ben-Califa, Nathalie
AU - Kashman, Yoel
N1 - Funding Information:
We thank Dr. N. Tal and Mr. S. Hauptman for performing the electrospray and FAB mass measurements. This work was supported by grant #365/09 from the Israel Science Foundation (ISF) .
PY - 2010/6/12
Y1 - 2010/6/12
N2 - Seven new nitrogenous macrolides, designated salarins D-J (4-10), closely related to salarins A-C (1-3), have been isolated from the Madagascar Fascaplysinopsis sp. sponge. The structure and relative stereochemistry of compounds 4-10 were elucidated by interpretation of MS, COSY, HSQC, HMBC, and NOESY spectra. Salarin B's structure (2), based on the structure of salarin J (10), is now amended to also incorporate the C-14 to -17 THF ring system. All compounds were evaluated for their cytotoxicity against K562 and UT-7 human leukemia cells. While salarins D, E, H, and J displayed dose and time dependent inhibition of proliferation, salarins F and I were not active in these assays.
AB - Seven new nitrogenous macrolides, designated salarins D-J (4-10), closely related to salarins A-C (1-3), have been isolated from the Madagascar Fascaplysinopsis sp. sponge. The structure and relative stereochemistry of compounds 4-10 were elucidated by interpretation of MS, COSY, HSQC, HMBC, and NOESY spectra. Salarin B's structure (2), based on the structure of salarin J (10), is now amended to also incorporate the C-14 to -17 THF ring system. All compounds were evaluated for their cytotoxicity against K562 and UT-7 human leukemia cells. While salarins D, E, H, and J displayed dose and time dependent inhibition of proliferation, salarins F and I were not active in these assays.
KW - Fascaplysinopsis sp.
KW - Leukemia cells
KW - Nitrogenous macrolide
KW - Salarins
KW - Sponge
UR - http://www.scopus.com/inward/record.url?scp=77953119909&partnerID=8YFLogxK
U2 - 10.1016/j.tet.2010.04.035
DO - 10.1016/j.tet.2010.04.035
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AN - SCOPUS:77953119909
VL - 66
SP - 4339
EP - 4345
JO - Tetrahedron
JF - Tetrahedron
SN - 0040-4020
IS - 24
ER -