Salarins D-J, seven new nitrogenous macrolides from the madagascar sponge Fascaplysinopsis sp.

Ashgan Bishara, Amira Rudi, Maurice Aknin, Drorit Neumann, Nathalie Ben-Califa, Yoel Kashman

Research output: Contribution to journalArticlepeer-review

Abstract

Seven new nitrogenous macrolides, designated salarins D-J (4-10), closely related to salarins A-C (1-3), have been isolated from the Madagascar Fascaplysinopsis sp. sponge. The structure and relative stereochemistry of compounds 4-10 were elucidated by interpretation of MS, COSY, HSQC, HMBC, and NOESY spectra. Salarin B's structure (2), based on the structure of salarin J (10), is now amended to also incorporate the C-14 to -17 THF ring system. All compounds were evaluated for their cytotoxicity against K562 and UT-7 human leukemia cells. While salarins D, E, H, and J displayed dose and time dependent inhibition of proliferation, salarins F and I were not active in these assays.

Original languageEnglish
Pages (from-to)4339-4345
Number of pages7
JournalTetrahedron
Volume66
Issue number24
DOIs
StatePublished - 12 Jun 2010

Keywords

  • Fascaplysinopsis sp.
  • Leukemia cells
  • Nitrogenous macrolide
  • Salarins
  • Sponge

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