Salarins A and B and tulearin A: New cytotoxic sponge-derived macrolides

Ashgan Bishara; Amira Rudi; Maurice Aknin; Drorit Neumann; Nathalie Ben-Califa; Yoel Kashman

doi:10.1021/ol702221v

Salarins A and B and tulearin A: New cytotoxic sponge-derived macrolides

Ashgan Bishara
, Amira Rudi
, Maurice Aknin
, Drorit Neumann
, Nathalie Ben-Califa
, Yoel Kashman^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

(Chemical Equation Presented) Three novel nitrogenous macrolides designated salarin A and B (1 and 2) and tulearin A (3) were isolated from the Madagascar Fascaplysinopsis sp. sponge. The structures of the compounds were elucidated by interpretation of MS and 1D and 2D NMR spectra. Both salarins carry an acetylcarbamate moiety, and in addition, 1 contains a triacylamine group and 2 a methoxymethylketone lactam. Tulearin A carries the naturally rare carbamate ester. The compounds were found to be toxic to brine shrimp larvae, and salarin A and tulearin A were also cytotoxic to leukemia cells.

Original language	English
Pages (from-to)	153-156
Number of pages	4
Journal	Organic Letters
Volume	10
Issue number	2
DOIs	https://doi.org/10.1021/ol702221v
State	Published - 17 Jan 2008

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title = "Salarins A and B and tulearin A: New cytotoxic sponge-derived macrolides",

abstract = "(Chemical Equation Presented) Three novel nitrogenous macrolides designated salarin A and B (1 and 2) and tulearin A (3) were isolated from the Madagascar Fascaplysinopsis sp. sponge. The structures of the compounds were elucidated by interpretation of MS and 1D and 2D NMR spectra. Both salarins carry an acetylcarbamate moiety, and in addition, 1 contains a triacylamine group and 2 a methoxymethylketone lactam. Tulearin A carries the naturally rare carbamate ester. The compounds were found to be toxic to brine shrimp larvae, and salarin A and tulearin A were also cytotoxic to leukemia cells.",

author = "Ashgan Bishara and Amira Rudi and Maurice Aknin and Drorit Neumann and Nathalie Ben-Califa and Yoel Kashman",

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AU - Bishara, Ashgan

AU - Rudi, Amira

AU - Aknin, Maurice

AU - Neumann, Drorit

AU - Ben-Califa, Nathalie

AU - Kashman, Yoel

PY - 2008/1/17

Y1 - 2008/1/17

N2 - (Chemical Equation Presented) Three novel nitrogenous macrolides designated salarin A and B (1 and 2) and tulearin A (3) were isolated from the Madagascar Fascaplysinopsis sp. sponge. The structures of the compounds were elucidated by interpretation of MS and 1D and 2D NMR spectra. Both salarins carry an acetylcarbamate moiety, and in addition, 1 contains a triacylamine group and 2 a methoxymethylketone lactam. Tulearin A carries the naturally rare carbamate ester. The compounds were found to be toxic to brine shrimp larvae, and salarin A and tulearin A were also cytotoxic to leukemia cells.

AB - (Chemical Equation Presented) Three novel nitrogenous macrolides designated salarin A and B (1 and 2) and tulearin A (3) were isolated from the Madagascar Fascaplysinopsis sp. sponge. The structures of the compounds were elucidated by interpretation of MS and 1D and 2D NMR spectra. Both salarins carry an acetylcarbamate moiety, and in addition, 1 contains a triacylamine group and 2 a methoxymethylketone lactam. Tulearin A carries the naturally rare carbamate ester. The compounds were found to be toxic to brine shrimp larvae, and salarin A and tulearin A were also cytotoxic to leukemia cells.

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Salarins A and B and tulearin A: New cytotoxic sponge-derived macrolides

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