Salarins A and B and tulearin A: New cytotoxic sponge-derived macrolides

Ashgan Bishara, Amira Rudi, Maurice Aknin, Drorit Neumann, Nathalie Ben-Califa, Yoel Kashman

Research output: Contribution to journalArticlepeer-review

Abstract

(Chemical Equation Presented) Three novel nitrogenous macrolides designated salarin A and B (1 and 2) and tulearin A (3) were isolated from the Madagascar Fascaplysinopsis sp. sponge. The structures of the compounds were elucidated by interpretation of MS and 1D and 2D NMR spectra. Both salarins carry an acetylcarbamate moiety, and in addition, 1 contains a triacylamine group and 2 a methoxymethylketone lactam. Tulearin A carries the naturally rare carbamate ester. The compounds were found to be toxic to brine shrimp larvae, and salarin A and tulearin A were also cytotoxic to leukemia cells.

Original languageEnglish
Pages (from-to)153-156
Number of pages4
JournalOrganic Letters
Volume10
Issue number2
DOIs
StatePublished - 17 Jan 2008

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