Salarin C, a new cytotoxic sponge-derived nitrogenous macrolide

Ashgan Bishara, Amira Rudi, Maurice Aknin, Drorit Neumann, Nathalie Ben-Califa, Yoel Kashman

Research output: Contribution to journalArticlepeer-review

Abstract

A novel nitrogenous macrolide, designated salarin C (3), was isolated from the Madagascan sponge Fascaplysinopsis sp. The structure of the compound was elucidated by interpretation of MS and 1D and 2D NMR spectra. Salarin C is closely related to salarin A and is considered to be the precursor of salarins A and B (1,2). Air oxidation was found to transform 3 to 1. Salarin C was found to inhibit cell proliferation of human leukeamic cell lines UT-7 and K562 and the murine pro-B cell line Ba/F3 at concentrations of 0.0005-0.5 mg/ml. A possible biogenesis is discussed.

Original languageEnglish
Pages (from-to)4355-4358
Number of pages4
JournalTetrahedron Letters
Volume49
Issue number28
DOIs
StatePublished - 7 Jul 2008

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