Safety, tolerability and effectiveness of a novel 20 Hz rTMS protocol targeting dorsomedial prefrontal cortex in major depression: An open-label case series

Jean Philippe Miron; Kfir Feffer; Robin F.H. Cash; D. Derakhshan; John Min Seok Kim; P. Fettes; P. Giacobbe; Daniel M. Blumberger; Zafiris J. Daskalakis; Jonathan Downar

doi:10.1016/j.brs.2019.06.020

Safety, tolerability and effectiveness of a novel 20 Hz rTMS protocol targeting dorsomedial prefrontal cortex in major depression: An open-label case series

Jean Philippe Miron^*, Kfir Feffer, Robin F.H. Cash, D. Derakhshan, John Min Seok Kim, P. Fettes, P. Giacobbe, Daniel M. Blumberger, Zafiris J. Daskalakis, Jonathan Downar

^*Corresponding author for this work

Clinical Departments

Research output: Contribution to journal › Letter › peer-review

Original language	English
Pages (from-to)	1319-1321
Number of pages	3
Journal	Brain Stimulation
Volume	12
Issue number	5
DOIs	https://doi.org/10.1016/j.brs.2019.06.020
State	Published - 1 Sep 2019

Keywords

DMPFC
High-frequency
TMS
TRD
Transcranial magnetic stimulation
Treatment-resistant depression

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10.1016/j.brs.2019.06.020

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Miron, J. P., Feffer, K., Cash, R. F. H., Derakhshan, D., Kim, J. M. S., Fettes, P., Giacobbe, P., Blumberger, D. M., Daskalakis, Z. J., & Downar, J. (2019). Safety, tolerability and effectiveness of a novel 20 Hz rTMS protocol targeting dorsomedial prefrontal cortex in major depression: An open-label case series. Brain Stimulation, 12(5), 1319-1321. https://doi.org/10.1016/j.brs.2019.06.020

@article{b3dbf623653541ebad770d39d640c7f3,

title = "Safety, tolerability and effectiveness of a novel 20 Hz rTMS protocol targeting dorsomedial prefrontal cortex in major depression: An open-label case series",

keywords = "DMPFC, High-frequency, TMS, TRD, Transcranial magnetic stimulation, Treatment-resistant depression",

author = "Miron, {Jean Philippe} and Kfir Feffer and Cash, {Robin F.H.} and D. Derakhshan and Kim, {John Min Seok} and P. Fettes and P. Giacobbe and Blumberger, {Daniel M.} and Daskalakis, {Zafiris J.} and Jonathan Downar",

note = "Funding Information: Authors JPM, KF, DD, JMSK, PF, RFHC and PG report no conflicts of interest. JD reports research grants from CIHR, the National Institute of Mental Health, Brain Canada, the Canadian Biomarker Integration Network in Depression, the Ontario Brain Institute, the Weston Foundation, the Klarman Family Foundation, the Arrell Family Foundation, and the Buchan Family Foundation, travel stipends from Lundbeck and ANT Neuro, in-kind equipment support for investigator-initiated trials from MagVenture, and is an advisor for BrainCheck, TMS Neuro Solutions, and Restorative Brain Clinics. DMB has received research support from the CIHR, NIH, Brain Canada and the Temerty Family through the CAMH Foundation and the Campbell Research Institute. He received research support and in-kind equipment support for an investigator-initiated study from Brainsway Ltd., and he is the principal site investigator for three sponsor-initiated studies for Brainsway Ltd. He received in-kind equipment support from Magventure for investigator-initiated research. He received medication supplies for an investigator-initiated trial from Indivior. He has participated in an advisory board for Janssen. In the last 5 years, ZJD has received research and equipment in-kind support for an investigator-initiated study through Brainsway Inc and Magventure Inc. His work was supported by the Ontario Mental Health Foundation (OMHF), the Canadian Institutes of Health Research (CIHR), the National Institutes of Mental Health (NIMH) and the Temerty Family and Grant Family and through the Centre for Addiction and Mental Health (CAMH) Foundation and the Campbell Institute. Funding Information: Authors JPM, KF, DD, JMSK, PF, RFHC and PG report no conflicts of interest. JD reports research grants from CIHR , the National Institute of Mental Health , Brain Canada , the Canadian Biomarker Integration Network in Depression , the Ontario Brain Institute , the Weston Foundation , the Klarman Family Foundation , the Arrell Family Foundation , and the Buchan Family Foundation , travel stipends from Lundbeck and ANT Neuro , in-kind equipment support for investigator-initiated trials from MagVenture, and is an advisor for BrainCheck, TMS Neuro Solutions, and Restorative Brain Clinics. DMB has received research support from the CIHR, NIH , Brain Canada and the Temerty Family through the CAMH Foundation and the Campbell Research Institute . He received research support and in-kind equipment support for an investigator-initiated study from Brainsway Ltd., and he is the principal site investigator for three sponsor-initiated studies for Brainsway Ltd. He received in-kind equipment support from Magventure for investigator-initiated research. He received medication supplies for an investigator-initiated trial from Indivior. He has participated in an advisory board for Janssen. In the last 5 years, ZJD has received research and equipment in-kind support for an investigator-initiated study through Brainsway Inc and Magventure Inc. His work was supported by the Ontario Mental Health Foundation (OMHF), the Canadian Institutes of Health Research (CIHR), the National Institutes of Mental Health (NIMH) and the Temerty Family and Grant Family and through the Centre for Addiction and Mental Health (CAMH) Foundation and the Campbell Institute. ",

year = "2019",

month = sep,

day = "1",

doi = "10.1016/j.brs.2019.06.020",

language = "אנגלית",

volume = "12",

pages = "1319--1321",

journal = "Brain Stimulation",

issn = "1935-861X",

publisher = "Elsevier Inc.",

number = "5",

}

Miron, JP, Feffer, K, Cash, RFH, Derakhshan, D, Kim, JMS, Fettes, P, Giacobbe, P, Blumberger, DM, Daskalakis, ZJ & Downar, J 2019, 'Safety, tolerability and effectiveness of a novel 20 Hz rTMS protocol targeting dorsomedial prefrontal cortex in major depression: An open-label case series', Brain Stimulation, vol. 12, no. 5, pp. 1319-1321. https://doi.org/10.1016/j.brs.2019.06.020

TY - JOUR

T1 - Safety, tolerability and effectiveness of a novel 20 Hz rTMS protocol targeting dorsomedial prefrontal cortex in major depression

T2 - An open-label case series

AU - Miron, Jean Philippe

AU - Feffer, Kfir

AU - Cash, Robin F.H.

AU - Derakhshan, D.

AU - Kim, John Min Seok

AU - Fettes, P.

AU - Giacobbe, P.

AU - Blumberger, Daniel M.

AU - Daskalakis, Zafiris J.

AU - Downar, Jonathan

N1 - Funding Information: Authors JPM, KF, DD, JMSK, PF, RFHC and PG report no conflicts of interest. JD reports research grants from CIHR, the National Institute of Mental Health, Brain Canada, the Canadian Biomarker Integration Network in Depression, the Ontario Brain Institute, the Weston Foundation, the Klarman Family Foundation, the Arrell Family Foundation, and the Buchan Family Foundation, travel stipends from Lundbeck and ANT Neuro, in-kind equipment support for investigator-initiated trials from MagVenture, and is an advisor for BrainCheck, TMS Neuro Solutions, and Restorative Brain Clinics. DMB has received research support from the CIHR, NIH, Brain Canada and the Temerty Family through the CAMH Foundation and the Campbell Research Institute. He received research support and in-kind equipment support for an investigator-initiated study from Brainsway Ltd., and he is the principal site investigator for three sponsor-initiated studies for Brainsway Ltd. He received in-kind equipment support from Magventure for investigator-initiated research. He received medication supplies for an investigator-initiated trial from Indivior. He has participated in an advisory board for Janssen. In the last 5 years, ZJD has received research and equipment in-kind support for an investigator-initiated study through Brainsway Inc and Magventure Inc. His work was supported by the Ontario Mental Health Foundation (OMHF), the Canadian Institutes of Health Research (CIHR), the National Institutes of Mental Health (NIMH) and the Temerty Family and Grant Family and through the Centre for Addiction and Mental Health (CAMH) Foundation and the Campbell Institute. Funding Information: Authors JPM, KF, DD, JMSK, PF, RFHC and PG report no conflicts of interest. JD reports research grants from CIHR , the National Institute of Mental Health , Brain Canada , the Canadian Biomarker Integration Network in Depression , the Ontario Brain Institute , the Weston Foundation , the Klarman Family Foundation , the Arrell Family Foundation , and the Buchan Family Foundation , travel stipends from Lundbeck and ANT Neuro , in-kind equipment support for investigator-initiated trials from MagVenture, and is an advisor for BrainCheck, TMS Neuro Solutions, and Restorative Brain Clinics. DMB has received research support from the CIHR, NIH , Brain Canada and the Temerty Family through the CAMH Foundation and the Campbell Research Institute . He received research support and in-kind equipment support for an investigator-initiated study from Brainsway Ltd., and he is the principal site investigator for three sponsor-initiated studies for Brainsway Ltd. He received in-kind equipment support from Magventure for investigator-initiated research. He received medication supplies for an investigator-initiated trial from Indivior. He has participated in an advisory board for Janssen. In the last 5 years, ZJD has received research and equipment in-kind support for an investigator-initiated study through Brainsway Inc and Magventure Inc. His work was supported by the Ontario Mental Health Foundation (OMHF), the Canadian Institutes of Health Research (CIHR), the National Institutes of Mental Health (NIMH) and the Temerty Family and Grant Family and through the Centre for Addiction and Mental Health (CAMH) Foundation and the Campbell Institute.

PY - 2019/9/1

Y1 - 2019/9/1

KW - DMPFC

KW - High-frequency

KW - TMS

KW - TRD

KW - Transcranial magnetic stimulation

KW - Treatment-resistant depression

UR - http://www.scopus.com/inward/record.url?scp=85070674160&partnerID=8YFLogxK

U2 - 10.1016/j.brs.2019.06.020

DO - 10.1016/j.brs.2019.06.020

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.letter???

C2 - 31266722

AN - SCOPUS:85070674160

SN - 1935-861X

VL - 12

SP - 1319

EP - 1321

JO - Brain Stimulation

JF - Brain Stimulation

IS - 5

ER -

Safety, tolerability and effectiveness of a novel 20 Hz rTMS protocol targeting dorsomedial prefrontal cortex in major depression: An open-label case series

Keywords

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