Safety of ovarian conservation and fertility preservation in advanced borderline ovarian tumors

Limor Helpman, Mario E. Beiner, Sarit Aviel-Ronen, Tamar Perri, Liat Hogen, Ariella Jakobson-Setton, Gilad Ben-Baruch, Jacob Korach

Research output: Contribution to journalArticlepeer-review


Objective To assess the impact of a fertility-sparing approach on disease recurrence in women with advanced borderline ovarian tumors. Design Historic cohort study. Setting A tertiary referral center for gynecological oncology patients and a university teaching hospital. Patient(s) Consecutive patients with advanced borderline ovarian tumors defined as stage IC and above, treated at a single institution during a span of 30 years. Intervention(s) Data on surgical approach (e.g., fertility sparing, ovarian conserving) as well as histopathology, disease stage, CA-125 level, and use of chemotherapy were collected from the medical records, and their impact on disease recurrence was assessed. Main Outcome Measure(s) Recurrence-free interval. Its association with the type of surgery and with other clinical and pathological features was assessed using the Kaplan Meier and Cox proportional hazards methods. Result(s) Fifty-nine patients with advanced disease were identified. Median follow-up was 55.3 months. Mean age at diagnosis was 35 years. Most of the tumors (51, 84.4%) had serous histology. Twenty-seven patients (45.8%) developed recurrences and 6 (10%) died of their disease. Mean time to recurrence was 30.6 months. Of 44 women ≤40 years, 33 (75%) had a fertility-sparing procedure. Fertility preservation was not associated with disease recurrence. A total of 34 pregnancies and 26 live births were documented among 21 patients attempting conception. Conclusion(s) Borderline ovarian tumors carry a favorable prognosis, even at an advanced stage. Fertility preservation was not found to be associated with an increased risk of relapse in young patients with advanced disease, and may be reasonably considered.

Original languageEnglish
Pages (from-to)138-144
Number of pages7
JournalFertility and Sterility
Issue number1
StatePublished - 1 Jul 2015


  • Borderline ovarian tumor
  • fertility preservation
  • ovarian conservation


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