TY - JOUR
T1 - Safety of fentanyl for peripherally inserted central catheter in non-intubated infants in the neonatal intensive care unit /692/700/565/411 /692/700/1720 /692/700/565/2194 /692/700/565/411 /692/700/1720 article
AU - Kasirer, Yair
AU - Shah, Vibhuti
AU - Yoon, Eugene W.
AU - Bromiker, Ruben
AU - McNair, Carol
AU - Taddio, Anna
N1 - Publisher Copyright:
© 2018 Nature America, Inc., part of Springer Nature.
PY - 2018/5/1
Y1 - 2018/5/1
N2 - Objective: To evaluate the safety of fentanyl in non-intubated infants undergoing peripherally inserted central catheter (PICC) placement. Methods: A retrospective chart review of PICC placements over a 3 years' period. We compared the 12h periods before and after fentanyl for clinically significant cardiorespiratory events (spells). Results: Of the 998 neonates screened, 258 were eligible. The mean standard deviation gestational age was 34.1 (4.3) weeks and the median (inter-quartile range) postnatal age was 4 (7, 11) days. The mean (standard deviation) fentanyl dose was 0.6 (0.2) μg/kg. Respiratory depression occurred only in two infants (prevalence rate = 0.78%, 95% CI (0, 1.85)). No cases of hypotension or chest wall rigidity occurred. There was no evidence of an increase in the number of infants with spells or in the number of spells per infant (p = 0.34 and p = 0.06, respectively). Conclusion: Fentanyl appears to be associated with only a small risk of respiratory depression in non-intubated infants.
AB - Objective: To evaluate the safety of fentanyl in non-intubated infants undergoing peripherally inserted central catheter (PICC) placement. Methods: A retrospective chart review of PICC placements over a 3 years' period. We compared the 12h periods before and after fentanyl for clinically significant cardiorespiratory events (spells). Results: Of the 998 neonates screened, 258 were eligible. The mean standard deviation gestational age was 34.1 (4.3) weeks and the median (inter-quartile range) postnatal age was 4 (7, 11) days. The mean (standard deviation) fentanyl dose was 0.6 (0.2) μg/kg. Respiratory depression occurred only in two infants (prevalence rate = 0.78%, 95% CI (0, 1.85)). No cases of hypotension or chest wall rigidity occurred. There was no evidence of an increase in the number of infants with spells or in the number of spells per infant (p = 0.34 and p = 0.06, respectively). Conclusion: Fentanyl appears to be associated with only a small risk of respiratory depression in non-intubated infants.
UR - http://www.scopus.com/inward/record.url?scp=85046671920&partnerID=8YFLogxK
U2 - 10.1038/s41372-018-0101-3
DO - 10.1038/s41372-018-0101-3
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C2 - 29740192
AN - SCOPUS:85046671920
SN - 0743-8346
VL - 38
SP - 526
EP - 529
JO - Journal of Perinatology
JF - Journal of Perinatology
IS - 5
ER -