Safety of eptifibatide for subcortical stroke progression

Sheryl Martin-Schild*, Hashem Shaltoni, Anitha T. Abraham, Andrew D. Barreto, Hen Hallevi, Nicole R. Gonzales, James C. Grotta, Sean I. Savitz

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Background: There is no proven treatment for stroke progression in patients with subcortical infarcts. Eptifibatide, a glycoprotein IIb/IIIa inhibitor, might halt stroke progression by improving flow in the microcirculation. Methods: We conducted a retrospective analysis of patients with subcortical stroke who experienced deterioration and were treated with eptifibatide (loading dose 180 μg/kg; infusion 2 μg/kg/min) for 24-48 h. Oral antiplatelet agents were started 6 h before discontinuation of eptifibatide. Results: Twenty-four patients with subcortical strokes were treated. The median admission NIHSS score was 5.0, which worsened to 8.5 (motor 5.0) before starting eptifibatide. The median NIHSS score 24 h after starting eptifibatide was 5.5. At 24 h, 42% had motor NIHSS scores less than or equal to pre-deterioration scores (50% for total NIHSS), and 50% had improved at least 1 motor point compared to pre-eptifibatide scores, which was sustained until hospital discharge. At discharge, the median total NIHSS score was 4.5. Ninety-two percent of patients were discharged home or to inpatient rehabilitation. Treatment was stopped early in 1 case due to a platelet drop <100,000/μl. No systemic or intracerebral bleeding occurred. Conclusions: Eptifibatide infusion may be safe in patients with subcortical ischemic strokes. Future studies are needed to test the safety and potential efficacy of this agent in subcortical stroke progression.

Original languageEnglish
Pages (from-to)595-600
Number of pages6
JournalCerebrovascular Diseases
Issue number6
StatePublished - Nov 2009
Externally publishedYes


FundersFunder number
National Institute of Neurological Disorders and StrokeT32NS007412
National Institute of Neurological Disorders and Stroke


    • Eptifibatide
    • Stroke
    • Subcortical infarct


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