TY - JOUR
T1 - Runx1/AML1 in leukemia
T2 - disrupted association with diverse protein partners
AU - Perry, Chava
AU - Eldor, Amiram
AU - Soreq, Hermona
N1 - Funding Information:
Chava Perry, MD, is the incumbent of a basic research fellowship from the Israel Ministry of Health. All authors contributed equally to the preparation of this manuscript, which was drafted by C. Perry.
PY - 2002
Y1 - 2002
N2 - Runx1/AML1, a chromosome 21q22 hematopoietic regulator, is frequently translocated in leukemia. Its protein product, a relatively weak transcriptional activator, becomes an effective transcriptional enhancer or repressor, when co-operating with transcriptional co-activators or co-repressors. Runx1/AML1 association with its partners is disrupted in leukemia. For example, Runx1/AML1 mutations and translocations (e.g. t(8;21), t(12;21) and t(3;21)) impair binding of Runx1/AML1-CBFβ complexes to Runt motifs in myelopoietically active promoters, preventing normal hematopoiesis. However, Runx1/AML1-associated translocations are not leukemogenic in animal models, suggesting the involvement of yet unidentified regulatory proteins. New candidates are cholinesterases, inhibition of which increases leukemic risk in a manner potentially associated with Runx1/AML1.
AB - Runx1/AML1, a chromosome 21q22 hematopoietic regulator, is frequently translocated in leukemia. Its protein product, a relatively weak transcriptional activator, becomes an effective transcriptional enhancer or repressor, when co-operating with transcriptional co-activators or co-repressors. Runx1/AML1 association with its partners is disrupted in leukemia. For example, Runx1/AML1 mutations and translocations (e.g. t(8;21), t(12;21) and t(3;21)) impair binding of Runx1/AML1-CBFβ complexes to Runt motifs in myelopoietically active promoters, preventing normal hematopoiesis. However, Runx1/AML1-associated translocations are not leukemogenic in animal models, suggesting the involvement of yet unidentified regulatory proteins. New candidates are cholinesterases, inhibition of which increases leukemic risk in a manner potentially associated with Runx1/AML1.
KW - AML1/ETO
KW - Cholinesterase
KW - Chromosomal translocation
KW - Hematopoietic malignancies
KW - Runx1/AML1
KW - Transcription
UR - http://www.scopus.com/inward/record.url?scp=0036137654&partnerID=8YFLogxK
U2 - 10.1016/S0145-2126(01)00128-X
DO - 10.1016/S0145-2126(01)00128-X
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.shortsurvey???
C2 - 11792409
AN - SCOPUS:0036137654
SN - 0145-2126
VL - 26
SP - 221
EP - 228
JO - Leukemia Research
JF - Leukemia Research
IS - 3
ER -
