Abstract

Background: In January 2015, Tajikistan introduced the monovalent rotavirus vaccine into the national immunization program. Our objective was to estimate pre-vaccine burden of rotavirus-associated hospitalizations in children <5 years of age in Tajikistan. Methods: During January 2013–December 2014, active surveillance for acute gastroenteritis (AGE)-associated hospitalizations in children <5 years of age was conducted by sentinel surveillance site staff. Patients’ demographic and clinical data were summarized and a stool sample was collected. An Enzyme Linked Immunosorbent Assay was used for diagnosis of rotavirus infection and subset of the specimens was sent for polymerase chain reaction (PCR) genotyping. Results: Of 2860 eligible children enrolled and tested, 1207 (42%) were positive for rotavirus. An increase in the number and proportion of rotavirus cases attributed to rotavirus season, with positivity rates >40%, was annually observed during June–September. The median age of rotavirus patients was 9 months and 939/1207 (78%) rotavirus patients were aged 6–23 months. Most (1097/1203; 91%) rotavirus patients were treated with intravenous fluids. G1P[8] was the predominant genotype during both years of surveillance, accounting for 133/222 (60%) of genotyped cases. Conclusion: Rotavirus is a major cause of hospitalization due to severe AGE in children <5 years of age in Tajikistan, accounting for >40% of cases. Continued, enhanced rotavirus surveillance may allow documentation of changes in rotavirus disease burden following vaccine introduction and assessment of vaccine effectiveness.

Original languageEnglish
Pages (from-to)7794-7797
Number of pages4
JournalVaccine
Volume36
Issue number51
DOIs
StatePublished - 14 Dec 2018

Funding

FundersFunder number
Vaccine Alliance
World Health Organization

    Keywords

    • Acute gastroenteritis
    • Children
    • Hospitalizations
    • Rotavirus
    • Tajikistan

    Fingerprint

    Dive into the research topics of 'Rotavirus hospitalizations among children <5 years of age—Tajikistan, 2013–2014'. Together they form a unique fingerprint.

    Cite this