Room temperature ADP induced first stage hyperaggregation of human blood platelets: a previously undescribed phenomenon and its relationship to spontaneous cold induced platelet aggregation

Ian J. Cohen*, Jacob Fuchs, Chaim Kaplinski, Judith Krugliak, Batia Stark, Ruth Vogel, Itzhak Weinberger, Zvi Rotenberg, Jacob Agmon, Zohara Jerushalmyi, Rina Zaizov

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

ADP induced human platelet aggregation was shown to be accentuated when tested at 20‐30°C as increased sensitivity and as a greater change of optical density although second stage aggregation and the release reaction did not occur. This previously undescribed phenomenon is defined as room temperature ADP induced first stage hyperaggregation. Aggregation, which occurs under the above mentioned conditions with a quantity of ADP insufficient to maintain the aggregation (usually less than 1 5 μm), is reversible when the temperature is raised to 3 7°C. After rewarming to these temperatures, second stage aggregation appeared in the presence of larger quantities of ADP (usually more than 2 μm) and could be blocked by aspirin. The absence of the release reaction was demonstrated with a lumi‐aggregometer. Spontaneous cold induced platelet aggregation seen after chilling platelets to 0‐4°C is shown to be a distinct phenomenon.

Original languageEnglish
Pages (from-to)331-334
Number of pages4
JournalBritish Journal of Haematology
Volume65
Issue number3
DOIs
StatePublished - Mar 1987
Externally publishedYes

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