TY - JOUR
T1 - Role of ultrasound for assessment of psoriatic arthritis patients with fibromyalgia
AU - Polachek, Ari
AU - Furer, Victoria
AU - Zureik, Mirna
AU - Nevo, Sharon
AU - Mendel, Liran
AU - Levartovsky, David
AU - Wollman, Jonathan
AU - Aloush, Valerie
AU - Tzemach, Reut
AU - Elalouf, Ofir
AU - Anouk, Marina
AU - Berman, Mark
AU - Kaufman, Ilana
AU - Carmi, Or
AU - Lahat, Yael
AU - Eviatar, Tali
AU - Padova, Hagit
AU - Sarbagil-Maman, Hagit
AU - Borok, Sara
AU - Broyde, Adi
AU - Eder, Lihi
AU - Paran, Daphna
AU - Elkayam, Ori
N1 - Publisher Copyright:
© Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.
PY - 2021/12/1
Y1 - 2021/12/1
N2 - Objective To investigate whether ultrasonography (US), as an objective imaging modality, can optimise the evaluation of disease activity in psoriatic arthritis (PsA) patients with concomitant fibromyalgia syndrome (FMS). Methods The study population included 156 consecutive PsA patients who were recruited prospectively and fulfilled the ClASsification criteria for Psoriatic ARthritis criteria. The patients underwent complete clinical evaluation including assessment of fulfilment of the 2016 fibromyalgia classification criteria. All of the patients underwent US evaluation including 52 joints, 40 tendons and 14 entheses. The US score was based on the summation of a semiquantitative score (including synovitis, tenosynovitis and enthesitis). Scoring was performed by a sonographer blinded to the clinical data. Spearman's correlation coefficient and multivariate linear regression models were used to examine the association of FMS with clinical and the US scores. Results Forty-two patients (26.9%) with coexisting PsA and FMS were compared with 114 (73.1%) PsA patients without FMS. Patients with PsA and FMS had significantly increased scores for clinical composite indices, including non-Minimal Disease Activity, Composite Psoriatic Disease Activity Index (CPDAI), Disease Activity for Psoriatic Arthritis (DAPSA) and Psoriatic Arthritis Disease Activity Score (PASDAS) (p<0.001). In contrast, the total US score and its subcategories were similar for those with and without FMS. The total US score significantly correlated with CPDAI, DAPSA and PASDAS (p<0.001) in the PsA without FMS but not in the PsA with FMS group. FMS was significantly associated with higher clinical scores (p<0.001) but not with the US score (multivariable linear regression models). Conclusions US has significantly greater value than composite clinical scores in the assessment of disease activity in PsA patients with FMS.
AB - Objective To investigate whether ultrasonography (US), as an objective imaging modality, can optimise the evaluation of disease activity in psoriatic arthritis (PsA) patients with concomitant fibromyalgia syndrome (FMS). Methods The study population included 156 consecutive PsA patients who were recruited prospectively and fulfilled the ClASsification criteria for Psoriatic ARthritis criteria. The patients underwent complete clinical evaluation including assessment of fulfilment of the 2016 fibromyalgia classification criteria. All of the patients underwent US evaluation including 52 joints, 40 tendons and 14 entheses. The US score was based on the summation of a semiquantitative score (including synovitis, tenosynovitis and enthesitis). Scoring was performed by a sonographer blinded to the clinical data. Spearman's correlation coefficient and multivariate linear regression models were used to examine the association of FMS with clinical and the US scores. Results Forty-two patients (26.9%) with coexisting PsA and FMS were compared with 114 (73.1%) PsA patients without FMS. Patients with PsA and FMS had significantly increased scores for clinical composite indices, including non-Minimal Disease Activity, Composite Psoriatic Disease Activity Index (CPDAI), Disease Activity for Psoriatic Arthritis (DAPSA) and Psoriatic Arthritis Disease Activity Score (PASDAS) (p<0.001). In contrast, the total US score and its subcategories were similar for those with and without FMS. The total US score significantly correlated with CPDAI, DAPSA and PASDAS (p<0.001) in the PsA without FMS but not in the PsA with FMS group. FMS was significantly associated with higher clinical scores (p<0.001) but not with the US score (multivariable linear regression models). Conclusions US has significantly greater value than composite clinical scores in the assessment of disease activity in PsA patients with FMS.
KW - arthritis
KW - fibromyalgia
KW - inflammation
KW - psoriatic
KW - ultrasonography
UR - http://www.scopus.com/inward/record.url?scp=85120154146&partnerID=8YFLogxK
U2 - 10.1136/annrheumdis-2021-220562
DO - 10.1136/annrheumdis-2021-220562
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C2 - 34215648
AN - SCOPUS:85120154146
SN - 0003-4967
VL - 80
SP - 1553
EP - 1558
JO - Annals of the Rheumatic Diseases
JF - Annals of the Rheumatic Diseases
IS - 12
ER -