Role of thrombin in central nervous system injury and disease

Nathan A. Shlobin; Meirav Har-Even; Ze’Ev Itsekson-Hayosh; Sagi Harnof; Chaim G. Pick

doi:10.3390/biom11040562

Role of thrombin in central nervous system injury and disease

Nathan A. Shlobin^*, Meirav Har-Even^*, Ze’Ev Itsekson-Hayosh, Sagi Harnof, Chaim G. Pick^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

36 Scopus citations

Abstract

Thrombin is a Na⁺-activated allosteric serine protease of the chymotrypsin family involved in coagulation, inflammation, cell protection, and apoptosis. Increasingly, the role of thrombin in the brain has been explored. Low concentrations of thrombin are neuroprotective, while high concentrations exert pathological effects. However, greater attention regarding the involvement of thrombin in normal and pathological processes in the central nervous system is warranted. In this review, we explore the mechanisms of thrombin action, localization, and functions in the central nervous system and describe the involvement of thrombin in stroke and intracerebral hemorrhage, neurodegenerative diseases, epilepsy, traumatic brain injury, and primary central nervous system tumors. We aim to comprehensively characterize the role of thrombin in neurological disease and injury.

Original language	English
Article number	562
Journal	Biomolecules
Volume	11
Issue number	4
DOIs	https://doi.org/10.3390/biom11040562
State	Published - Apr 2021

Keywords

Blood–brain barrier
Glioblastoma
Neurodegenerative diseases
Neuroinflammation
Protease-activated receptor
Prothrombin
TBI
Thrombin

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/biom11040562

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title = "Role of thrombin in central nervous system injury and disease",

abstract = "Thrombin is a Na+-activated allosteric serine protease of the chymotrypsin family involved in coagulation, inflammation, cell protection, and apoptosis. Increasingly, the role of thrombin in the brain has been explored. Low concentrations of thrombin are neuroprotective, while high concentrations exert pathological effects. However, greater attention regarding the involvement of thrombin in normal and pathological processes in the central nervous system is warranted. In this review, we explore the mechanisms of thrombin action, localization, and functions in the central nervous system and describe the involvement of thrombin in stroke and intracerebral hemorrhage, neurodegenerative diseases, epilepsy, traumatic brain injury, and primary central nervous system tumors. We aim to comprehensively characterize the role of thrombin in neurological disease and injury.",

keywords = "Blood–brain barrier, Glioblastoma, Neurodegenerative diseases, Neuroinflammation, Protease-activated receptor, Prothrombin, TBI, Thrombin",

author = "Shlobin, {Nathan A.} and Meirav Har-Even and Ze{\textquoteright}Ev Itsekson-Hayosh and Sagi Harnof and Pick, {Chaim G.}",

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AU - Harnof, Sagi

AU - Pick, Chaim G.

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KW - Neurodegenerative diseases

KW - Neuroinflammation

KW - Protease-activated receptor

KW - Prothrombin

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Role of thrombin in central nervous system injury and disease

Abstract

Keywords

UN SDGs

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