Role of the spleen and lymphocytes in regulation of the circulating platelet number in mice

H. Bessler, E. M. Mandel, M. Djaldetti

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

The role of the spleen in the regulation of the circulating platelet number was studied in mice. The increased 75Se-Met incorporation found after removal of the spleen indicates that postsplenectomy thrombocytosis is due to enhanced platelet production. The increased thrombopoietic activity observed in the plasma of splenectomized mice proves the presence of a humoral factor which mediates this process. Administration of spleen lymphocytes of control mice caused mild thrombocytopenia and prevented postsplenectomy thrombocytosis in splenectomized animals. Moreover, culture medium obtained from peripheral blood and spleen lymphocytes contained a substance which induces thrombocytopenia when injected into control mice. The mechanism by which the spleen and lymphocytes affect the amount of circulating platelets is discussed.

Original languageEnglish
Pages (from-to)760-768
Number of pages9
JournalJournal of Laboratory and Clinical Medicine
Volume91
Issue number5
StatePublished - 1978
Externally publishedYes

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