Role of the newborn’s sex in mixed maternal-newborn lymphocyte culture reactivity

Luise Komlos; L. Sirota; J. Notman; F. Dulitzky; J. Hart; J. Goldman; I. Halbrecht

doi:10.1159/000293620

Role of the newborn’s sex in mixed maternal-newborn lymphocyte culture reactivity

Luise Komlos^*, L. Sirota, J. Notman, F. Dulitzky, J. Hart, J. Goldman, I. Halbrecht

^*Corresponding author for this work

Clinical Departments

Rabin Medical Center Israel

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

One-way-stimulated mixed mother-newborn lymphocyte cultures(MMNLC) from male and female newborns were evaluated and compared shortly after delivery. Newborn sex-correlated differences were observed in the strength of the MMNLC reactivity with responding maternal as well as newborn cells. The reactivity of MMNLC with responding maternal cells from male as compared to female newborns was significantly less inhibited in maternal and newborn serum. The inhibitory effect of maternal serum on maternal and male newborn lymphocytes in MMNLC seems to be correlated to the sex of the previous child delivered and was significantly lower when the present as well as the previous baby were of the same sex, e.g. 2 boys. The results suggest that fetal-male-specific Y-chromosome-correlated histocompatibility antigens may specifically influence the maternal immune response to her fetus.

Original language	English
Pages (from-to)	62-69
Number of pages	8
Journal	Gynecologic and Obstetric Investigation
Volume	27
Issue number	2
DOIs	https://doi.org/10.1159/000293620
State	Published - 1989

Keywords

Maternal immune response
Mixed mother–newborn lymphocyte cultures
Y–correlated histocompatibility antigens

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10.1159/000293620

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abstract = "One-way-stimulated mixed mother-newborn lymphocyte cultures(MMNLC) from male and female newborns were evaluated and compared shortly after delivery. Newborn sex-correlated differences were observed in the strength of the MMNLC reactivity with responding maternal as well as newborn cells. The reactivity of MMNLC with responding maternal cells from male as compared to female newborns was significantly less inhibited in maternal and newborn serum. The inhibitory effect of maternal serum on maternal and male newborn lymphocytes in MMNLC seems to be correlated to the sex of the previous child delivered and was significantly lower when the present as well as the previous baby were of the same sex, e.g. 2 boys. The results suggest that fetal-male-specific Y-chromosome-correlated histocompatibility antigens may specifically influence the maternal immune response to her fetus.",

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AU - Komlos, Luise

AU - Sirota, L.

AU - Notman, J.

AU - Dulitzky, F.

AU - Hart, J.

AU - Goldman, J.

AU - Halbrecht, I.

PY - 1989

Y1 - 1989

N2 - One-way-stimulated mixed mother-newborn lymphocyte cultures(MMNLC) from male and female newborns were evaluated and compared shortly after delivery. Newborn sex-correlated differences were observed in the strength of the MMNLC reactivity with responding maternal as well as newborn cells. The reactivity of MMNLC with responding maternal cells from male as compared to female newborns was significantly less inhibited in maternal and newborn serum. The inhibitory effect of maternal serum on maternal and male newborn lymphocytes in MMNLC seems to be correlated to the sex of the previous child delivered and was significantly lower when the present as well as the previous baby were of the same sex, e.g. 2 boys. The results suggest that fetal-male-specific Y-chromosome-correlated histocompatibility antigens may specifically influence the maternal immune response to her fetus.

AB - One-way-stimulated mixed mother-newborn lymphocyte cultures(MMNLC) from male and female newborns were evaluated and compared shortly after delivery. Newborn sex-correlated differences were observed in the strength of the MMNLC reactivity with responding maternal as well as newborn cells. The reactivity of MMNLC with responding maternal cells from male as compared to female newborns was significantly less inhibited in maternal and newborn serum. The inhibitory effect of maternal serum on maternal and male newborn lymphocytes in MMNLC seems to be correlated to the sex of the previous child delivered and was significantly lower when the present as well as the previous baby were of the same sex, e.g. 2 boys. The results suggest that fetal-male-specific Y-chromosome-correlated histocompatibility antigens may specifically influence the maternal immune response to her fetus.

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Role of the newborn’s sex in mixed maternal-newborn lymphocyte culture reactivity

Abstract

Keywords

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