Role of siroliumus, a novel immunosuppressive drug in heart and lung transplantation

David Shitrit, Alex Yussim, Mordechai R. Kramer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Lung and heart transplantation has become an accepted therapeutic option for patients with end-stage disease. However, the calcineurin-inhibitor-based immunosuppression often causes renal impairment. Therefore, sirolimus, a novel immunosuppressive agent, may serve as an alternative or complementary agent to calcineurin inhibitors. The aim of this review was to summarize the role of sirolimus in lung and heart transplantation. Although only a few, small studies have been conducted so far, the drug's mechanisms of action and low-toxicity profile make it a highly promising option.

Original languageEnglish
Pages (from-to)892-897
Number of pages6
JournalRespiratory Medicine
Volume98
Issue number9
DOIs
StatePublished - Sep 2004

Keywords

  • Immunosuppression
  • Rejection
  • Sirolimus
  • Transplantation

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