TY - JOUR
T1 - Role of protease inhibition in myocardial preservation following ischemia and reperfusion
AU - Gurevitch, J.
AU - Paz, Y.
AU - Barak, J.
AU - Matsa, M.
AU - Kramer, A.
AU - Pevni, D.
AU - Hochhauser, E.
AU - Yakirevich, V.
PY - 1994
Y1 - 1994
N2 - Aprotinin, a naturally occurring protease inhibitor, in concentrations of 106 KIU/L was found to have no effect on myocardial performance in normally perfused isolated rat hearts, before ischemia. Given during the preischemic period, the drug had a significant protective effect on the reperfused hearts, following cardioplegic ischemia: better contractility upon reperfusion (p < 0.011), faster decline of the ischemic contracture, higher coronary flow (p < 0.025), lower AV-difference (p < 0.05), and lower CPK levels (p < 0.01).
AB - Aprotinin, a naturally occurring protease inhibitor, in concentrations of 106 KIU/L was found to have no effect on myocardial performance in normally perfused isolated rat hearts, before ischemia. Given during the preischemic period, the drug had a significant protective effect on the reperfused hearts, following cardioplegic ischemia: better contractility upon reperfusion (p < 0.011), faster decline of the ischemic contracture, higher coronary flow (p < 0.025), lower AV-difference (p < 0.05), and lower CPK levels (p < 0.01).
KW - Aprotinin
KW - Ischemia
KW - Myocardial reperfusion
UR - http://www.scopus.com/inward/record.url?scp=0028672561&partnerID=8YFLogxK
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AN - SCOPUS:0028672561
SN - 0021-9509
VL - 35
SP - 95
EP - 98
JO - Journal of Cardiovascular Surgery
JF - Journal of Cardiovascular Surgery
IS - SUPPL. 1-6
ER -
