TY - JOUR
T1 - Role of prolonged stimulation of tamoxifen therapy in the etiology of endometrial sarcomas
AU - Altaras, Marco M.
AU - Aviram, Rami
AU - Cohen, Ilan
AU - Cordoba, Mario
AU - Yarkoni, Shai
AU - Beyth, Yoram
PY - 1993/5
Y1 - 1993/5
N2 - We present the first case of heterologous mixed mesodermal tumor that developed 9 years following tamoxifen therapy in a climacteric woman with no previous pelvic irradiation and was initially treated by total abdominal hysterectomy and bilateral salpingo-oophorectomy. She continued tamoxifen therapy for 2 years, following the initial treatment, until the diagnosis of a recurrent tumor by laparotomy. The patient died of the disease 5 months subsequent to the second surgery. The association of prolonged unopposed estrogenic stimulation, with tamoxifen as a possible etiologic factor in the development of endometrial sarcomas, is discussed.
AB - We present the first case of heterologous mixed mesodermal tumor that developed 9 years following tamoxifen therapy in a climacteric woman with no previous pelvic irradiation and was initially treated by total abdominal hysterectomy and bilateral salpingo-oophorectomy. She continued tamoxifen therapy for 2 years, following the initial treatment, until the diagnosis of a recurrent tumor by laparotomy. The patient died of the disease 5 months subsequent to the second surgery. The association of prolonged unopposed estrogenic stimulation, with tamoxifen as a possible etiologic factor in the development of endometrial sarcomas, is discussed.
UR - http://www.scopus.com/inward/record.url?scp=0027207776&partnerID=8YFLogxK
U2 - 10.1006/gyno.1993.1118
DO - 10.1006/gyno.1993.1118
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AN - SCOPUS:0027207776
SN - 0090-8258
VL - 49
SP - 255
EP - 258
JO - Gynecologic Oncology
JF - Gynecologic Oncology
IS - 2
ER -
