Role of prolonged excessive estrogen stimulation in the pathogenesis of endometrial sarcomas: Two cases and a review of the literature

Marco M. Altaras, Richard Jaffe, Ilan Cohen, Arieh Gruber, Ilana Yanai-Inbar, Joelle Bernheim

Research output: Contribution to journalArticlepeer-review

Abstract

Two cases of endometrial sarcoma that developed many years after exposure to unopposed exogenous and endogenous estrogens, with no previous pelvic irradiation, are described. The literature is reviewed and the possible effect of prolonged unopposed estrogen stimulation is suggested as an etiologic factor in such extremely rare conditions. These cases add additional support to the assumption that prolonged and excessive endogenous or exogenous unopposed estrogen stimulation of the uterus may increase the risk of endometrial sarcoma.

Original languageEnglish
Pages (from-to)273-277
Number of pages5
JournalGynecologic Oncology
Volume38
Issue number2
DOIs
StatePublished - Aug 1990

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