Role of nitric oxide in glycerol-induced acute renal failure in rats

A. Maree, G. Peer, D. Schwartz, I. Serban, M. Blum, Y. Wollman, S. Cabili, A. Iaina*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


EDRF results from the metabolism of L-arginine. N-omega-nitro-L-arginine is a nitric oxide synthase inhibitor (L-arginine competitive inhibitor). Acute renal failure was induced by i.m glycerol (50%) 5 ml/kg bw. L-arginine: 3 mg/kg bw/min for 60 min before and 60 min after glycerol administration. L-arginine inhibitor (150 μg/kg bw/min for 120 min). C(in), C(pah) and FE(Na)% were measured immediately or 24 h after glycerol (mean of three periods of 20 min). A second series of similar experiments was done in dehydrated (16 h) rats with a high dose of glycerol (50% solution, 10 ml/kg bw). L-arginine ameliorates the severity of ARF immediately after glycerol administration and enhances the recovery of glycerol-induced ARF. The L-arginine inhibitor resulted in a more severe ARF. Urinary cGMP decreased significantly after glycerol administration. It is concluded that nitric oxide has an important pathogenetic role in the glycerol induced ARF.

Original languageEnglish
Pages (from-to)78-81
Number of pages4
JournalNephrology Dialysis Transplantation
Issue numberSUPPL. 4
StatePublished - 1994
Externally publishedYes


  • ARF
  • EDRF
  • Glycerol
  • L-arginine
  • Nitric oxide
  • Nitric oxide synthase inhibitor
  • Rats


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