@article{25772a138189481f995d6eb5e143d19e,
title = "Role of multiple binding sites in the inhibition of NADH oxidase by piericidin and rotenone",
abstract = "Scatchard plots indicate that 14C-piericidin A and -rotenone bind at 2 specific sites per mole of NADH dehydrogenase in ETP, but the titer found for complex I or mersalyl-treated ETP more closely approximates 1. The curves for inhibition of NADH oxidase by piericidin and rotenone are sigmoidal; this results from an unequal contribution of the 2 specific sites to the inhibition. An unspecific binding site also contributes to the inhibition in a manner reversed by washing the particles with bovine serum albumin (BSA). In contrast, inhibition of NADH-CoQ reductase activity is due entirely to binding at specific site(s) because BSA does not restore activity.",
author = "M. Gutman and Singer, {Thomas P.} and Casida, {John E.}",
note = "Funding Information: This investigation was supported by the United States Public Health Service (HE 10027 and ESGM 00049), the National Science Foundation (GB 82481, the American Heart Association (67 7061, the American Cancer Society (P 5311, and the Atomic Energy Commission (Contract AT(ll-11-34, Project Agreement 113).",
year = "1969",
month = nov,
day = "6",
doi = "10.1016/0006-291X(69)90854-7",
language = "אנגלית",
volume = "37",
pages = "615--622",
journal = "Biochemical and Biophysical Research Communications",
issn = "0006-291X",
publisher = "Elsevier B.V.",
number = "4",
}