Role of medial forebrain bundle catecholaminergic fibers in the modulation of glucocorticoid negative feedback effects

S. Feldman; R. A. Siegel; J. Weidenfeld; N. Conforti; E. Melamed

doi:10.1016/0006-8993(83)90684-4

Role of medial forebrain bundle catecholaminergic fibers in the modulation of glucocorticoid negative feedback effects

S. Feldman^*, R. A. Siegel, J. Weidenfeld, N. Conforti, E. Melamed

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

The possible role of medial forebrain bundle (MFB) catecholaminergic fibers in the previously observed MFB-mediated modulation of hypothalamic sensitivity to glucocorticoid negative feedback effects has been investigated. MFB catecholaminergic fibers were destroyed by bilateral MFB injections of 6-hydroxydopamine (6-OHDA) to adult male rats. The inhibitory effect of dexamethasone (10 μg, i.p., 4h) upon the adrenocortical secretory response to ether stress, as estimated by serum corticosterone levels, was enhanced in the 6-OHDA-treated animals, as compared to vehicle-injected controls. This study suggests that MFB noradrenergic neurons are at least partially responsible for the MFB-mediated modulation of hypothalamic sensitivity to glucocorticoid hormones.

Original language	English
Pages (from-to)	297-300
Number of pages	4
Journal	Brain Research
Volume	260
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(83)90684-4
State	Published - 7 Feb 1983
Externally published	Yes

Keywords

6-hydroxydopamine
adrenocortical function
glucocorticoid feedback
medial forebrain bundle

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10.1016/0006-8993(83)90684-4

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abstract = "The possible role of medial forebrain bundle (MFB) catecholaminergic fibers in the previously observed MFB-mediated modulation of hypothalamic sensitivity to glucocorticoid negative feedback effects has been investigated. MFB catecholaminergic fibers were destroyed by bilateral MFB injections of 6-hydroxydopamine (6-OHDA) to adult male rats. The inhibitory effect of dexamethasone (10 μg, i.p., 4h) upon the adrenocortical secretory response to ether stress, as estimated by serum corticosterone levels, was enhanced in the 6-OHDA-treated animals, as compared to vehicle-injected controls. This study suggests that MFB noradrenergic neurons are at least partially responsible for the MFB-mediated modulation of hypothalamic sensitivity to glucocorticoid hormones.",

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AU - Melamed, E.

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Role of medial forebrain bundle catecholaminergic fibers in the modulation of glucocorticoid negative feedback effects

Abstract

Keywords

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