Role of medial forebrain bundle catecholaminergic fibers in the modulation of glucocorticoid negative feedback effects

S. Feldman*, R. A. Siegel, J. Weidenfeld, N. Conforti, E. Melamed

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

The possible role of medial forebrain bundle (MFB) catecholaminergic fibers in the previously observed MFB-mediated modulation of hypothalamic sensitivity to glucocorticoid negative feedback effects has been investigated. MFB catecholaminergic fibers were destroyed by bilateral MFB injections of 6-hydroxydopamine (6-OHDA) to adult male rats. The inhibitory effect of dexamethasone (10 μg, i.p., 4h) upon the adrenocortical secretory response to ether stress, as estimated by serum corticosterone levels, was enhanced in the 6-OHDA-treated animals, as compared to vehicle-injected controls. This study suggests that MFB noradrenergic neurons are at least partially responsible for the MFB-mediated modulation of hypothalamic sensitivity to glucocorticoid hormones.

Original languageEnglish
Pages (from-to)297-300
Number of pages4
JournalBrain Research
Volume260
Issue number2
DOIs
StatePublished - 7 Feb 1983
Externally publishedYes

Keywords

  • 6-hydroxydopamine
  • adrenocortical function
  • glucocorticoid feedback
  • medial forebrain bundle

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