Role of mast cell-derived adenosine in cancer

Yaara Gorzalczany, Ronit Sagi-Eisenberg

Research output: Contribution to journalReview articlepeer-review

Abstract

Accumulating evidence has highlighted the accumulation of mast cells (MCs) in tumors. However, their impact on tumor development remained controversial. Indeed, cumulative data indicate an enigmatic role for MCs in cancer, whereby depending on the circumstances, which still need to be resolved, MCs function to promote or restrict tumor growth. By responding to multiple stimuli MCs release multiple inflammatory mediators, that contribute to the resolution of infection and resistance to envenomation, but also have the potency to promote or inhibit malignancy. Thus, MCs seem to possess the power to define tumor projections. Given this remarkable plasticity of MC responsiveness, there is an urgent need of understanding how MCs are activated in the tumor microenvironment (TME). We have recently reported on the direct activation of MCs upon contact with cancer cells by a mechanism involving an autocrine formation of adenosine and signaling by the A3 adenosine receptor. Here we summarized the evidence on the role of adenosine signaling in cancer, in MC mediated inflammation and in the MC-cancer crosstalk.

Original languageEnglish
Article number2603
JournalInternational Journal of Molecular Sciences
Volume20
Issue number10
DOIs
StatePublished - 2 May 2019

Keywords

  • Adenosine
  • Cancer
  • Mast cells
  • Tumor microenvironment

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