TY - JOUR
T1 - Role of induction chemotherapy prior to chemoradiation in head and neck squamous cell cancer-systematic review and meta-analysis
AU - Vidal, Liat
AU - Aharon, Irit Ben
AU - Limon, Dror
AU - Cohen, Ezra
AU - Popovtzer, Aron
N1 - Publisher Copyright:
© Wolters Kluwer Health, Inc. All rights reserved.
PY - 2017
Y1 - 2017
N2 - The objective of this study was to reviewand assess the impact of additional induction chemotherapy to concomitant chemoradiation in head and neck squamous cell cancer.We performed a comparative systematic review and meta-analysis of clinical trials of induction chemotherapy + chemoradiation and chemoradiation alone in this setting. We identified trials randomizing 1314 patients (published 2004-2015). A non-statistically significant trend was observed in favor of induction chemotherapy + chemoradiation on overall survival (hazard ratio, 0.88; 95% confidence interval, 0.75-1.04). Disease controlwas superior in the induction chemotherapy + chemoradiation group (hazard ratio, 0.69; 95%confidence interval, 0.57-0.83). The rate of complete response improved with induction chemotherapy compared with concomitant chemoradiation (relative risk, 1.52; 95% confidence interval, 1.20-1.92). This study showed no benefit of induction chemotherapy + chemoradiation on overall survival. However, improved complete response rate and death certificate- only registrations may imply that selected patients may benefit from induction chemotherapy.
AB - The objective of this study was to reviewand assess the impact of additional induction chemotherapy to concomitant chemoradiation in head and neck squamous cell cancer.We performed a comparative systematic review and meta-analysis of clinical trials of induction chemotherapy + chemoradiation and chemoradiation alone in this setting. We identified trials randomizing 1314 patients (published 2004-2015). A non-statistically significant trend was observed in favor of induction chemotherapy + chemoradiation on overall survival (hazard ratio, 0.88; 95% confidence interval, 0.75-1.04). Disease controlwas superior in the induction chemotherapy + chemoradiation group (hazard ratio, 0.69; 95%confidence interval, 0.57-0.83). The rate of complete response improved with induction chemotherapy compared with concomitant chemoradiation (relative risk, 1.52; 95% confidence interval, 1.20-1.92). This study showed no benefit of induction chemotherapy + chemoradiation on overall survival. However, improved complete response rate and death certificate- only registrations may imply that selected patients may benefit from induction chemotherapy.
KW - HPV
KW - Induction chemotherapy
KW - Meta-analysis
KW - TPF
UR - http://www.scopus.com/inward/record.url?scp=85018984865&partnerID=8YFLogxK
U2 - 10.1097/PPO.0000000000000253
DO - 10.1097/PPO.0000000000000253
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C2 - 28410291
AN - SCOPUS:85018984865
SN - 1528-9117
VL - 23
SP - 79
EP - 83
JO - Cancer Journal (United States)
JF - Cancer Journal (United States)
IS - 2
ER -