Role of induction chemotherapy prior to chemoradiation in head and neck squamous cell cancer-systematic review and meta-analysis

Liat Vidal, Irit Ben Aharon, Dror Limon, Ezra Cohen, Aron Popovtzer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

The objective of this study was to reviewand assess the impact of additional induction chemotherapy to concomitant chemoradiation in head and neck squamous cell cancer.We performed a comparative systematic review and meta-analysis of clinical trials of induction chemotherapy + chemoradiation and chemoradiation alone in this setting. We identified trials randomizing 1314 patients (published 2004-2015). A non-statistically significant trend was observed in favor of induction chemotherapy + chemoradiation on overall survival (hazard ratio, 0.88; 95% confidence interval, 0.75-1.04). Disease controlwas superior in the induction chemotherapy + chemoradiation group (hazard ratio, 0.69; 95%confidence interval, 0.57-0.83). The rate of complete response improved with induction chemotherapy compared with concomitant chemoradiation (relative risk, 1.52; 95% confidence interval, 1.20-1.92). This study showed no benefit of induction chemotherapy + chemoradiation on overall survival. However, improved complete response rate and death certificate- only registrations may imply that selected patients may benefit from induction chemotherapy.

Original languageEnglish
Pages (from-to)79-83
Number of pages5
JournalCancer journal (Sudbury, Mass.)
Volume23
Issue number2
DOIs
StatePublished - 2017

Keywords

  • HPV
  • Induction chemotherapy
  • Meta-analysis
  • TPF

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