Role of iL-1-mediated inflammation in tumor angiogenesis

Elena Voronov, Yaron Carmi, Ron N. Apte

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Angiogenesis, or generation of new blood vessels from pre-existing vessels, is an integral part of many physiological or pathological processes, including tumor growth. Physiological angiogenesis is a complex process controlled by different proangiogenic as well as antiangiogenic factors. For angiogenic induction, the balance between these pro- and anti-angiogenic factors in the microenvironment has to shift in favor of proangiogenic factors, either by upregulation of these pro-angiogenic factors or by downregulation of angiogenic inhibitors. Proinflammatory cytokines, such as IL-1 and TNFα , were found to be major pro-angiogenic stimuli of both physiological and pathological angiogenesis. The IL-1 family consists of pleiotropic proinflammatory and immunoregulatory cytokines, namely, IL-1α and IL-1β , and one antagonistic protein, the IL-1 receptor antagonist (IL-1Ra), which binds to IL-1 receptors without transmitting an activation signal and represents a physiological inhibitor of preformed IL-1. Previously, we described an important role for microenvironment IL-1, mainly IL-1β , in tumor angiogenesis. In this chapter, we analyze the role of microenvironment host- and tumor cell-derived IL-1 on angiogenesis and the role of inflammation in pathological angiogenesis.

Original languageEnglish
Title of host publicationImmune-Mediated Diseases
Subtitle of host publicationFrom Theory to Therapy
EditorsMichael Shurin, Yuri Smolkin
Pages265-270
Number of pages6
DOIs
StatePublished - 2007
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume601
ISSN (Print)0065-2598

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