Role of fibronectin in curli-mediated internalization

Uri Gophna, Tobias A. Oelschlaeger, Joerg Hacker, Eliora Z. Ron

Research output: Contribution to journalArticlepeer-review

Abstract

Curli fibers of Escherichia coli mediate internalization of bacteria by eukaryotic cells. As curli fibers bind fibronectin with high affinity, the role of fibronectin in the uptake process was studied. The experiments presented here support the involvement of fibronectin in internalization of bacteria. Furthermore, a peptide containing the RGD motif, responsible for interaction of fibronectin with cellular integrins, can strongly inhibit curli-mediated internalization. The ability of curli fibers to bind fibronectin can therefore be linked to virulence.

Original languageEnglish
Pages (from-to)55-58
Number of pages4
JournalFEMS Microbiology Letters
Volume212
Issue number1
DOIs
StatePublished - 18 Jun 2002

Keywords

  • Bacterial virulence
  • Colisepticemia
  • Curli fiber
  • Invasion
  • O78
  • RGD

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