Role of fibronectin in curli-mediated internalization

Uri Gophna; Tobias A. Oelschlaeger; Joerg Hacker; Eliora Z. Ron

doi:10.1016/S0378-1097(02)00703-6

Role of fibronectin in curli-mediated internalization

Uri Gophna, Tobias A. Oelschlaeger, Joerg Hacker, Eliora Z. Ron^*

^*Corresponding author for this work

Biotechnology

Research output: Contribution to journal › Article › peer-review

Abstract

Curli fibers of Escherichia coli mediate internalization of bacteria by eukaryotic cells. As curli fibers bind fibronectin with high affinity, the role of fibronectin in the uptake process was studied. The experiments presented here support the involvement of fibronectin in internalization of bacteria. Furthermore, a peptide containing the RGD motif, responsible for interaction of fibronectin with cellular integrins, can strongly inhibit curli-mediated internalization. The ability of curli fibers to bind fibronectin can therefore be linked to virulence.

Original language	English
Pages (from-to)	55-58
Number of pages	4
Journal	FEMS Microbiology Letters
Volume	212
Issue number	1
DOIs	https://doi.org/10.1016/S0378-1097(02)00703-6
State	Published - 18 Jun 2002

Keywords

Bacterial virulence
Colisepticemia
Curli fiber
Invasion
O78
RGD

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10.1016/S0378-1097(02)00703-6

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title = "Role of fibronectin in curli-mediated internalization",

abstract = "Curli fibers of Escherichia coli mediate internalization of bacteria by eukaryotic cells. As curli fibers bind fibronectin with high affinity, the role of fibronectin in the uptake process was studied. The experiments presented here support the involvement of fibronectin in internalization of bacteria. Furthermore, a peptide containing the RGD motif, responsible for interaction of fibronectin with cellular integrins, can strongly inhibit curli-mediated internalization. The ability of curli fibers to bind fibronectin can therefore be linked to virulence.",

keywords = "Bacterial virulence, Colisepticemia, Curli fiber, Invasion, O78, RGD",

author = "Uri Gophna and Oelschlaeger, {Tobias A.} and Joerg Hacker and Ron, {Eliora Z.}",

note = "Funding Information: This work was supported by the Center for Emerging Diseases and by the Manja and Morris Leigh Chair for Biophysics and Biotechnology.",

year = "2002",

month = jun,

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doi = "10.1016/S0378-1097(02)00703-6",

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T1 - Role of fibronectin in curli-mediated internalization

AU - Gophna, Uri

AU - Oelschlaeger, Tobias A.

AU - Hacker, Joerg

AU - Ron, Eliora Z.

N1 - Funding Information: This work was supported by the Center for Emerging Diseases and by the Manja and Morris Leigh Chair for Biophysics and Biotechnology.

PY - 2002/6/18

Y1 - 2002/6/18

N2 - Curli fibers of Escherichia coli mediate internalization of bacteria by eukaryotic cells. As curli fibers bind fibronectin with high affinity, the role of fibronectin in the uptake process was studied. The experiments presented here support the involvement of fibronectin in internalization of bacteria. Furthermore, a peptide containing the RGD motif, responsible for interaction of fibronectin with cellular integrins, can strongly inhibit curli-mediated internalization. The ability of curli fibers to bind fibronectin can therefore be linked to virulence.

AB - Curli fibers of Escherichia coli mediate internalization of bacteria by eukaryotic cells. As curli fibers bind fibronectin with high affinity, the role of fibronectin in the uptake process was studied. The experiments presented here support the involvement of fibronectin in internalization of bacteria. Furthermore, a peptide containing the RGD motif, responsible for interaction of fibronectin with cellular integrins, can strongly inhibit curli-mediated internalization. The ability of curli fibers to bind fibronectin can therefore be linked to virulence.

KW - Bacterial virulence

KW - Colisepticemia

KW - Curli fiber

KW - Invasion

KW - O78

KW - RGD

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SP - 55

EP - 58

JO - FEMS Microbiology Letters

JF - FEMS Microbiology Letters

IS - 1

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Role of fibronectin in curli-mediated internalization

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