Role of fibrin sealants in surgical procedures on patients with hemostatic disorders

Uri Martinowitz*, Sam Schulman, Henri Horoszowski, Michael Heim

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

Fibrin sealants have until now been used to a very limited extent in patients with a bleeding diathesis. The authors have accumulated experience from 8 minor and 40 major surgical procedures, plus 10 circumcisions and 118 tooth extractions in 106 patients suffering from hemophilia A, B, or von Willebrand's disease. Most of the patients had the severe form of the disease. The authors were able to show a reduction of blood loss and of requirements far replacement therapy with factor concentrates. The literature on the application of fibrin sealants in this group of patients, which mainly deals with dental procedures, is reviewed and compared with data from the current study. The composition of the glue is of major significance and is discussed in detail.

Original languageEnglish
Pages (from-to)65-75
Number of pages11
JournalClinical Orthopaedics and Related Research
Volume328
DOIs
StatePublished - 1996
Externally publishedYes

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