Role of DNA methylation in stable gene repression

Laura Lande-Diner, Jianmin Zhang, Ittai Ben-Porath, Ninette Amariglio, Ilana Keshet, Merav Hecht, Veronique Azuara, Amanda G. Fisher, Gideon Rechavi, Howard Cedar*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


A large fraction of the animal genome is maintained in a transcriptionally repressed state throughout development. By generating viable Dnmt1-/- mouse cells we have been able to study the effect of DNA methylation on both gene expression and chromatin structure. Our results confirm that the underlying methylation pattern has a profound effect on histone acetylation and is the major effector of me-H3(K4) in the animal genome. We demonstrate that many methylated genes are subject to additional repression mechanisms that also impact on histone acetylation, and the data suggest that late replication timing may play an important role in this process.

Original languageEnglish
Pages (from-to)12194-12200
Number of pages7
JournalJournal of Biological Chemistry
Issue number16
StatePublished - 20 Apr 2007


FundersFunder number
Medical Research CouncilMC_U120027516


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