Role of coagulation factor XIII (FXIII) in angiogenesis and tissue repair

Aida Inbal*, Rima Dardik

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Factor FXIII (FXIII) is a plasma transglutaminase that catalyzes the cross link formation between fibrin chains to stabilize the clot. Beside it s function in hemostasis FXIII has a role in wound healing and embryo implantation - processes that involve angiogenesis. In this review we discuss the role of FXIII in angiogenesis and the molecular mechanisms underlying its pro-angiogenic effect. In addition, FXIII role in wound repair is discussed.

Original languageEnglish
Pages (from-to)P162-P165
JournalPathophysiology of Haemostasis and Thrombosis
Volume35
Issue number1-2
DOIs
StatePublished - May 2006
Externally publishedYes

Keywords

  • Angiogenesis
  • Factor FXIII
  • Wound repair

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