TY - JOUR
T1 - Role of Children's Sex in Mixed Mother‐Child Lymphocyte Culture Reactivity
AU - KOMLOS, LUISE
AU - VARDIMON, DAVID
AU - NOTMANN, JAFFA
AU - ZAMIR, RINA
AU - KLEIN, TIRZA
AU - LIVNI, ELLA
AU - HART, JACOB
AU - GOLDMAN, JACK
AU - HALBRECHT, ISAAC
PY - 1990
Y1 - 1990
N2 - ABSTRACT: One‐way mixed mother‐child lymphocyte cultures (MMCLC) 4 to 20 years after the last delivery were studied with maternal responding and children's or fathers' stimulating cells (MMFLC) in 14 multiple child families with 18 sons and 20 daughters. HLA antigen typing locus A, B, DR was performed for all family members. As reported previously for newborn cells, a significantly increased maternal response could be observed in MMCLC with male as compared to female children's stimulating cells. Although the number of cases studied was small, it seems that the increased stimulating effect of male children's cells could also be observed when MMCLC values from children of different sex, and identical A,B,DR haplotypes were compared. In contrast to this, A,B,DR haploidentical children of the same sex seem to have a similar stimulating effect on the maternal response in MMCLC. The results suggest that male children's Y‐chromosome‐correlated minor histocompatibility antigens may additionally stimulate the maternal immune response in MMCLC. 1990 Munksgaard
AB - ABSTRACT: One‐way mixed mother‐child lymphocyte cultures (MMCLC) 4 to 20 years after the last delivery were studied with maternal responding and children's or fathers' stimulating cells (MMFLC) in 14 multiple child families with 18 sons and 20 daughters. HLA antigen typing locus A, B, DR was performed for all family members. As reported previously for newborn cells, a significantly increased maternal response could be observed in MMCLC with male as compared to female children's stimulating cells. Although the number of cases studied was small, it seems that the increased stimulating effect of male children's cells could also be observed when MMCLC values from children of different sex, and identical A,B,DR haplotypes were compared. In contrast to this, A,B,DR haploidentical children of the same sex seem to have a similar stimulating effect on the maternal response in MMCLC. The results suggest that male children's Y‐chromosome‐correlated minor histocompatibility antigens may additionally stimulate the maternal immune response in MMCLC. 1990 Munksgaard
KW - Y‐correlated histocompatibility antigens
KW - major histocompatibility complex
KW - maternal immune response
UR - http://www.scopus.com/inward/record.url?scp=0025375965&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0897.1990.tb01024.x
DO - 10.1111/j.1600-0897.1990.tb01024.x
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AN - SCOPUS:0025375965
VL - 22
SP - 4
EP - 8
JO - American Journal of Reproductive Immunology
JF - American Journal of Reproductive Immunology
SN - 1046-7408
IS - 1-2
ER -