Robust polytopic analysis of the feedback-control of Glycolysis in yeasts via some system norms

Eli Gershon; Uri Shaked; Liron Itzhaki

doi:10.1109/MED.2012.6265634

Robust polytopic analysis of the feedback-control of Glycolysis in yeasts via some system norms

Eli Gershon^*, Uri Shaked, Liron Itzhaki

^*Corresponding author for this work

School of Electrical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

3 Scopus citations

Abstract

In this paper we consider a well studied model of Glycolysis in yeast cells, leading from Glucose to the end product Ethanol, via a minimal nine steps mechanism. We first linearize each step in the pathway around a given set point and we then assemble the (originally nonlinear) system as a linear system subject to various polytopic uncertainties. We study the effect of the negative feedback-loop that is internally exerted on the system. We then probe the sensitivity of the system to variations in certain variables in order to asses the possible optimality of the system in the H ₂, H _∞ and the L ₂ - L ₂, L ₂ - L ₂ senses.

Original language	English
Title of host publication	2012 20th Mediterranean Conference on Control and Automation, MED 2012 - Conference Proceedings
Pages	176-181
Number of pages	6
DOIs	https://doi.org/10.1109/MED.2012.6265634
State	Published - 2012
Event	2012 20th Mediterranean Conference on Control and Automation, MED 2012 - Barcelona, Spain Duration: 3 Jul 2012 → 6 Jul 2012

Publication series

Name	2012 20th Mediterranean Conference on Control and Automation, MED 2012 - Conference Proceedings

Conference

Conference	2012 20th Mediterranean Conference on Control and Automation, MED 2012
Country/Territory	Spain
City	Barcelona
Period	3/07/12 → 6/07/12

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10.1109/MED.2012.6265634

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Gershon, E., Shaked, U., & Itzhaki, L. (2012). Robust polytopic analysis of the feedback-control of Glycolysis in yeasts via some system norms. In 2012 20th Mediterranean Conference on Control and Automation, MED 2012 - Conference Proceedings (pp. 176-181). Article 6265634 (2012 20th Mediterranean Conference on Control and Automation, MED 2012 - Conference Proceedings). https://doi.org/10.1109/MED.2012.6265634

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abstract = "In this paper we consider a well studied model of Glycolysis in yeast cells, leading from Glucose to the end product Ethanol, via a minimal nine steps mechanism. We first linearize each step in the pathway around a given set point and we then assemble the (originally nonlinear) system as a linear system subject to various polytopic uncertainties. We study the effect of the negative feedback-loop that is internally exerted on the system. We then probe the sensitivity of the system to variations in certain variables in order to asses the possible optimality of the system in the H 2, H ∞ and the L 2 - L 2, L 2 - L 2 senses.",

author = "Eli Gershon and Uri Shaked and Liron Itzhaki",

year = "2012",

doi = "10.1109/MED.2012.6265634",

language = "אנגלית",

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pages = "176--181",

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note = "2012 20th Mediterranean Conference on Control and Automation, MED 2012 ; Conference date: 03-07-2012 Through 06-07-2012",

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Gershon, E, Shaked, U & Itzhaki, L 2012, Robust polytopic analysis of the feedback-control of Glycolysis in yeasts via some system norms. in 2012 20th Mediterranean Conference on Control and Automation, MED 2012 - Conference Proceedings., 6265634, 2012 20th Mediterranean Conference on Control and Automation, MED 2012 - Conference Proceedings, pp. 176-181, 2012 20th Mediterranean Conference on Control and Automation, MED 2012, Barcelona, Spain, 3/07/12. https://doi.org/10.1109/MED.2012.6265634

Robust polytopic analysis of the feedback-control of Glycolysis in yeasts via some system norms. / Gershon, Eli; Shaked, Uri; Itzhaki, Liron.
2012 20th Mediterranean Conference on Control and Automation, MED 2012 - Conference Proceedings. 2012. p. 176-181 6265634 (2012 20th Mediterranean Conference on Control and Automation, MED 2012 - Conference Proceedings).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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Gershon E, Shaked U, Itzhaki L. Robust polytopic analysis of the feedback-control of Glycolysis in yeasts via some system norms. In 2012 20th Mediterranean Conference on Control and Automation, MED 2012 - Conference Proceedings. 2012. p. 176-181. 6265634. (2012 20th Mediterranean Conference on Control and Automation, MED 2012 - Conference Proceedings). doi: 10.1109/MED.2012.6265634

Robust polytopic analysis of the feedback-control of Glycolysis in yeasts via some system norms

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