Roadmap on Label-Free Super-Resolution Imaging

Vasily N. Astratov; Yair Ben Sahel; Yonina C. Eldar; Luzhe Huang; Aydogan Ozcan; Nikolay Zheludev; Junxiang Zhao; Zachary Burns; Zhaowei Liu; Evgenii Narimanov; Neha Goswami; Gabriel Popescu; Emanuel Pfitzner; Philipp Kukura; Yi Teng Hsiao; Chia Lung Hsieh; Brian Abbey; Alberto Diaspro; Aymeric LeGratiet; Paolo Bianchini; Natan T. Shaked; Bertrand Simon; Nicolas Verrier; Matthieu Debailleul; Olivier Haeberlé; Sheng Wang; Mengkun Liu; Yeran Bai; Ji Xin Cheng; Behjat S. Kariman; Katsumasa Fujita; Moshe Sinvani; Zeev Zalevsky; Xiangping Li; Guan Jie Huang; Shi Wei Chu; Omer Tzang; Dror Hershkovitz; Ori Cheshnovsky; Mikko J. Huttunen; Stefan G. Stanciu; Vera N. Smolyaninova; Igor I. Smolyaninov; Ulf Leonhardt; Sahar Sahebdivan; Zengbo Wang; Boris Luk'yanchuk; Limin Wu; Alexey V. Maslov; Boya Jin; Constantin R. Simovski; Stephane Perrin; Paul Montgomery; Sylvain Lecler

doi:10.1002/lpor.202200029

Roadmap on Label-Free Super-Resolution Imaging

Vasily N. Astratov^*, Yair Ben Sahel, Yonina C. Eldar, Luzhe Huang, Aydogan Ozcan, Nikolay Zheludev, Junxiang Zhao, Zachary Burns, Zhaowei Liu, Evgenii Narimanov, Neha Goswami, Gabriel Popescu, Emanuel Pfitzner, Philipp Kukura, Yi Teng Hsiao, Chia Lung Hsieh, Brian Abbey, Alberto Diaspro, Aymeric LeGratiet, Paolo BianchiniNatan T. Shaked, Bertrand Simon, Nicolas Verrier, Matthieu Debailleul, Olivier Haeberlé, Sheng Wang, Mengkun Liu, Yeran Bai, Ji Xin Cheng, Behjat S. Kariman, Katsumasa Fujita, Moshe Sinvani, Zeev Zalevsky, Xiangping Li, Guan Jie Huang, Shi Wei Chu, Omer Tzang, Dror Hershkovitz, Ori Cheshnovsky, Mikko J. Huttunen, Stefan G. Stanciu, Vera N. Smolyaninova, Igor I. Smolyaninov, Ulf Leonhardt, Sahar Sahebdivan, Zengbo Wang, Boris Luk'yanchuk, Limin Wu, Alexey V. Maslov, Boya Jin, Constantin R. Simovski, Stephane Perrin, Paul Montgomery, Sylvain Lecler

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

35 Scopus citations

Abstract

Label-free super-resolution (LFSR) imaging relies on light-scattering processes in nanoscale objects without a need for fluorescent (FL) staining required in super-resolved FL microscopy. The objectives of this Roadmap are to present a comprehensive vision of the developments, the state-of-the-art in this field, and to discuss the resolution boundaries and hurdles that need to be overcome to break the classical diffraction limit of the label-free imaging. The scope of this Roadmap spans from the advanced interference detection techniques, where the diffraction-limited lateral resolution is combined with unsurpassed axial and temporal resolution, to techniques with true lateral super-resolution capability that are based on understanding resolution as an information science problem, on using novel structured illumination, near-field scanning, and nonlinear optics approaches, and on designing superlenses based on nanoplasmonics, metamaterials, transformation optics, and microsphere-assisted approaches. To this end, this Roadmap brings under the same umbrella researchers from the physics and biomedical optics communities in which such studies have often been developing separately. The ultimate intent of this paper is to create a vision for the current and future developments of LFSR imaging based on its physical mechanisms and to create a great opening for the series of articles in this field.

Original language	English
Article number	2200029
Journal	Laser and Photonics Reviews
Volume	17
Issue number	12
DOIs	https://doi.org/10.1002/lpor.202200029
State	Published - Dec 2023

Funding

Funders	Funder number
Lomonosov Moscow State University
Brain Research Center of NTHU
California Department of Fish and Game
Ministry of Education in Taiwan
North Carolina Biotechnology Center
NSF I
Center for Metamaterials
Gordon and Betty Moore Foundation
Russian Science Foundation	20‐12‐00389
Engineering and Physical Sciences Research Council	EP/T03419X/1, EP/N00762X/1, EP/M009122/1
Academia Sinica	AS‐CDA‐107‐M06
Royal Society	IEC\R2\202178
Deutsche Forschungsgemeinschaft	PF991/1‐1
Engineering Research Centers	PHOTOMASS 819593
Research Council of Finland	320165
National Institutes of Health	R01AI141439, MOST‐112‐2321‐B‐002‐025, R01GM129709, MOST‐112‐2112‐M‐002‐032‐MY3, R01CA238191, R35GM136223
Special Program of “BASIS” Foundation	21‐2‐10‐39‐1
Ministry of Science and Technology	110‐2321‐B‐002‐012, MOST 108-2112-M-001-038-MY3, 108‐2112‐M‐001‐038‐MY3
Horizon 2020 Framework Programme	819593
Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii	RO‐NO‐2019‐0601
U CRC	1068050
Iowa Science Foundation	1294/18
Bangor University	S49610
Guangdong Provincial Innovation and Entrepreneurship Project	2016ZT06D081
Ministry of Education and Science of the Russian Federation	075‐15‐2022‐293
National Key Research and Development Program of China	2018YFB1107200, 2017YFA0204600
Australian Research Council	CE140100011
Ministry of Education - Singapore	MOE2016‐T3‐1‐006
National Science Foundation	1450962, 0939511, 1353368
Leverhulme Trust	RF‐2022‐659
National Natural Science Foundation of China	52033003, 51721002
MEDYCONAI	25 ⁄ 2021
Center for Advanced Computing and Imaging in Biomedicine of NTU	NTU‐112L900703

Keywords

biomedical imaging
diffraction limit
label-free imaging
near-field imaging
optical microscopy
structured illumination
super-resolution

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10.1002/lpor.202200029

Cite this

Astratov, V. N., Sahel, Y. B., Eldar, Y. C., Huang, L., Ozcan, A., Zheludev, N., Zhao, J., Burns, Z., Liu, Z., Narimanov, E., Goswami, N., Popescu, G., Pfitzner, E., Kukura, P., Hsiao, Y. T., Hsieh, C. L., Abbey, B., Diaspro, A., LeGratiet, A., ... Lecler, S. (2023). Roadmap on Label-Free Super-Resolution Imaging. Laser and Photonics Reviews, 17(12), Article 2200029. https://doi.org/10.1002/lpor.202200029

@article{03c8f7b1c307424a97454e942c965481,

title = "Roadmap on Label-Free Super-Resolution Imaging",

abstract = "Label-free super-resolution (LFSR) imaging relies on light-scattering processes in nanoscale objects without a need for fluorescent (FL) staining required in super-resolved FL microscopy. The objectives of this Roadmap are to present a comprehensive vision of the developments, the state-of-the-art in this field, and to discuss the resolution boundaries and hurdles that need to be overcome to break the classical diffraction limit of the label-free imaging. The scope of this Roadmap spans from the advanced interference detection techniques, where the diffraction-limited lateral resolution is combined with unsurpassed axial and temporal resolution, to techniques with true lateral super-resolution capability that are based on understanding resolution as an information science problem, on using novel structured illumination, near-field scanning, and nonlinear optics approaches, and on designing superlenses based on nanoplasmonics, metamaterials, transformation optics, and microsphere-assisted approaches. To this end, this Roadmap brings under the same umbrella researchers from the physics and biomedical optics communities in which such studies have often been developing separately. The ultimate intent of this paper is to create a vision for the current and future developments of LFSR imaging based on its physical mechanisms and to create a great opening for the series of articles in this field.",

keywords = "biomedical imaging, diffraction limit, label-free imaging, near-field imaging, optical microscopy, structured illumination, super-resolution",

author = "Astratov, {Vasily N.} and Sahel, {Yair Ben} and Eldar, {Yonina C.} and Luzhe Huang and Aydogan Ozcan and Nikolay Zheludev and Junxiang Zhao and Zachary Burns and Zhaowei Liu and Evgenii Narimanov and Neha Goswami and Gabriel Popescu and Emanuel Pfitzner and Philipp Kukura and Hsiao, {Yi Teng} and Hsieh, {Chia Lung} and Brian Abbey and Alberto Diaspro and Aymeric LeGratiet and Paolo Bianchini and Shaked, {Natan T.} and Bertrand Simon and Nicolas Verrier and Matthieu Debailleul and Olivier Haeberl{\'e} and Sheng Wang and Mengkun Liu and Yeran Bai and Cheng, {Ji Xin} and Kariman, {Behjat S.} and Katsumasa Fujita and Moshe Sinvani and Zeev Zalevsky and Xiangping Li and Huang, {Guan Jie} and Chu, {Shi Wei} and Omer Tzang and Dror Hershkovitz and Ori Cheshnovsky and Huttunen, {Mikko J.} and Stanciu, {Stefan G.} and Smolyaninova, {Vera N.} and Smolyaninov, {Igor I.} and Ulf Leonhardt and Sahar Sahebdivan and Zengbo Wang and Boris Luk'yanchuk and Limin Wu and Maslov, {Alexey V.} and Boya Jin and Simovski, {Constantin R.} and Stephane Perrin and Paul Montgomery and Sylvain Lecler",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors. Laser & Photonics Reviews published by Wiley-VCH GmbH.",

year = "2023",

month = dec,

doi = "10.1002/lpor.202200029",

language = "אנגלית",

volume = "17",

journal = "Laser and Photonics Reviews",

issn = "1863-8880",

publisher = "Wiley-VCH Verlag",

number = "12",

}

Astratov, VN, Sahel, YB, Eldar, YC, Huang, L, Ozcan, A, Zheludev, N, Zhao, J, Burns, Z, Liu, Z, Narimanov, E, Goswami, N, Popescu, G, Pfitzner, E, Kukura, P, Hsiao, YT, Hsieh, CL, Abbey, B, Diaspro, A, LeGratiet, A, Bianchini, P, Shaked, NT, Simon, B, Verrier, N, Debailleul, M, Haeberlé, O, Wang, S, Liu, M, Bai, Y, Cheng, JX, Kariman, BS, Fujita, K, Sinvani, M, Zalevsky, Z, Li, X, Huang, GJ, Chu, SW, Tzang, O, Hershkovitz, D, Cheshnovsky, O, Huttunen, MJ, Stanciu, SG, Smolyaninova, VN, Smolyaninov, II, Leonhardt, U, Sahebdivan, S, Wang, Z, Luk'yanchuk, B, Wu, L, Maslov, AV, Jin, B, Simovski, CR, Perrin, S, Montgomery, P & Lecler, S 2023, 'Roadmap on Label-Free Super-Resolution Imaging', Laser and Photonics Reviews, vol. 17, no. 12, 2200029. https://doi.org/10.1002/lpor.202200029

TY - JOUR

T1 - Roadmap on Label-Free Super-Resolution Imaging

AU - Astratov, Vasily N.

AU - Sahel, Yair Ben

AU - Eldar, Yonina C.

AU - Huang, Luzhe

AU - Ozcan, Aydogan

AU - Zheludev, Nikolay

AU - Zhao, Junxiang

AU - Burns, Zachary

AU - Liu, Zhaowei

AU - Narimanov, Evgenii

AU - Goswami, Neha

AU - Popescu, Gabriel

AU - Pfitzner, Emanuel

AU - Kukura, Philipp

AU - Hsiao, Yi Teng

AU - Hsieh, Chia Lung

AU - Abbey, Brian

AU - Diaspro, Alberto

AU - LeGratiet, Aymeric

AU - Bianchini, Paolo

AU - Shaked, Natan T.

AU - Simon, Bertrand

AU - Verrier, Nicolas

AU - Debailleul, Matthieu

AU - Haeberlé, Olivier

AU - Wang, Sheng

AU - Liu, Mengkun

AU - Bai, Yeran

AU - Cheng, Ji Xin

AU - Kariman, Behjat S.

AU - Fujita, Katsumasa

AU - Sinvani, Moshe

AU - Zalevsky, Zeev

AU - Li, Xiangping

AU - Huang, Guan Jie

AU - Chu, Shi Wei

AU - Tzang, Omer

AU - Hershkovitz, Dror

AU - Cheshnovsky, Ori

AU - Huttunen, Mikko J.

AU - Stanciu, Stefan G.

AU - Smolyaninova, Vera N.

AU - Smolyaninov, Igor I.

AU - Leonhardt, Ulf

AU - Sahebdivan, Sahar

AU - Wang, Zengbo

AU - Luk'yanchuk, Boris

AU - Wu, Limin

AU - Maslov, Alexey V.

AU - Jin, Boya

AU - Simovski, Constantin R.

AU - Perrin, Stephane

AU - Montgomery, Paul

AU - Lecler, Sylvain

PY - 2023/12

Y1 - 2023/12

N2 - Label-free super-resolution (LFSR) imaging relies on light-scattering processes in nanoscale objects without a need for fluorescent (FL) staining required in super-resolved FL microscopy. The objectives of this Roadmap are to present a comprehensive vision of the developments, the state-of-the-art in this field, and to discuss the resolution boundaries and hurdles that need to be overcome to break the classical diffraction limit of the label-free imaging. The scope of this Roadmap spans from the advanced interference detection techniques, where the diffraction-limited lateral resolution is combined with unsurpassed axial and temporal resolution, to techniques with true lateral super-resolution capability that are based on understanding resolution as an information science problem, on using novel structured illumination, near-field scanning, and nonlinear optics approaches, and on designing superlenses based on nanoplasmonics, metamaterials, transformation optics, and microsphere-assisted approaches. To this end, this Roadmap brings under the same umbrella researchers from the physics and biomedical optics communities in which such studies have often been developing separately. The ultimate intent of this paper is to create a vision for the current and future developments of LFSR imaging based on its physical mechanisms and to create a great opening for the series of articles in this field.

AB - Label-free super-resolution (LFSR) imaging relies on light-scattering processes in nanoscale objects without a need for fluorescent (FL) staining required in super-resolved FL microscopy. The objectives of this Roadmap are to present a comprehensive vision of the developments, the state-of-the-art in this field, and to discuss the resolution boundaries and hurdles that need to be overcome to break the classical diffraction limit of the label-free imaging. The scope of this Roadmap spans from the advanced interference detection techniques, where the diffraction-limited lateral resolution is combined with unsurpassed axial and temporal resolution, to techniques with true lateral super-resolution capability that are based on understanding resolution as an information science problem, on using novel structured illumination, near-field scanning, and nonlinear optics approaches, and on designing superlenses based on nanoplasmonics, metamaterials, transformation optics, and microsphere-assisted approaches. To this end, this Roadmap brings under the same umbrella researchers from the physics and biomedical optics communities in which such studies have often been developing separately. The ultimate intent of this paper is to create a vision for the current and future developments of LFSR imaging based on its physical mechanisms and to create a great opening for the series of articles in this field.

KW - biomedical imaging

KW - diffraction limit

KW - label-free imaging

KW - near-field imaging

KW - optical microscopy

KW - structured illumination

KW - super-resolution

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Roadmap on Label-Free Super-Resolution Imaging

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