TY - JOUR
T1 - RO 15-1788 produces naloxone-reversible analgesia in the rat
AU - Davidovich, Shaul
AU - Niv, David
AU - Geller, Eran
AU - Urca, Gideon
PY - 1988/1/27
Y1 - 1988/1/27
N2 - Intraperitoneal and intracerebroventricular administration of the benzodiazepine antagonist RO 15-1788 produced analgesia to both thermal and mechanical pain. This effect was reversed by pretreatment with the opioid antagonist naloxone but was unaffected by pretreatment with the benzodiazepine agonist midazolam. Furthermore, administration of the benzodiazepine antagonist RO 15-3505 was without analgesic effect. It is, therefore, proposed that the intrinsic action induced by RO 15-1788 is exerted via the indirect activation of endogeneous opioid systems and that the observed effect is not due to the action of the antagonist on the benzodiazepine receptor.
AB - Intraperitoneal and intracerebroventricular administration of the benzodiazepine antagonist RO 15-1788 produced analgesia to both thermal and mechanical pain. This effect was reversed by pretreatment with the opioid antagonist naloxone but was unaffected by pretreatment with the benzodiazepine agonist midazolam. Furthermore, administration of the benzodiazepine antagonist RO 15-3505 was without analgesic effect. It is, therefore, proposed that the intrinsic action induced by RO 15-1788 is exerted via the indirect activation of endogeneous opioid systems and that the observed effect is not due to the action of the antagonist on the benzodiazepine receptor.
KW - Analgesia
KW - Benzodiazepine antagonists, RO 15-1788
KW - Benzodiazepines
UR - http://www.scopus.com/inward/record.url?scp=0023905193&partnerID=8YFLogxK
U2 - 10.1016/0014-2999(88)90500-6
DO - 10.1016/0014-2999(88)90500-6
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
AN - SCOPUS:0023905193
SN - 0014-2999
VL - 146
SP - 175
EP - 179
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 1
ER -