RO 15-1788 produces naloxone-reversible analgesia in the rat

Shaul Davidovich, David Niv, Eran Geller, Gideon Urca*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Intraperitoneal and intracerebroventricular administration of the benzodiazepine antagonist RO 15-1788 produced analgesia to both thermal and mechanical pain. This effect was reversed by pretreatment with the opioid antagonist naloxone but was unaffected by pretreatment with the benzodiazepine agonist midazolam. Furthermore, administration of the benzodiazepine antagonist RO 15-3505 was without analgesic effect. It is, therefore, proposed that the intrinsic action induced by RO 15-1788 is exerted via the indirect activation of endogeneous opioid systems and that the observed effect is not due to the action of the antagonist on the benzodiazepine receptor.

Original languageEnglish
Pages (from-to)175-179
Number of pages5
JournalEuropean Journal of Pharmacology
Volume146
Issue number1
DOIs
StatePublished - 27 Jan 1988

Keywords

  • Analgesia
  • Benzodiazepine antagonists, RO 15-1788
  • Benzodiazepines

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