RNA modifications: What have we learned and where are we headed?

Michaela Frye, Samie R. Jaffrey, Tao Pan, Gideon Rechavi, Tsutomu Suzuki

Research output: Contribution to journalReview articlepeer-review

Abstract

Proper control of the transcriptome is key for diverse aspects of gene expression, cellular functions and development, and its disruption can result in disease. A rapidly accumulating wealth of studies are identifying and functionally characterizing diverse types of RNA base modifications in protein-coding and non-coding RNAs, which have energized the emerging field of 'epitranscriptomics'. In this Viewpoint article, five experts discuss our latest understanding of RNA modifications, including recommendations for best practices and visions for the future.

Original languageEnglish
Pages (from-to)365-372
Number of pages8
JournalNature Reviews Genetics
Volume17
Issue number6
DOIs
StatePublished - 1 Jun 2016

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