RNA interference - Small RNAs effectively fight viral hepatitis

Amir Shlomai*, Yosef Shaul

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

RNA interference (RNAi) is the process of sequence-specific gene silencing, initiated by double-stranded RNA that is homologous in sequence to the target gene. This unique phenomenon has been extensively investigated during the last few years not only in the context of its mechanism and its possible role in the regulation of gene expression and cell function, but also as a potential powerful tool for gene therapy. Targeting essential viral genes or oncogenic alleles are only some of the possible applications of RNAi in the field of gene-directed therapy. This review covers the potential use of RNAi against hepatitis B and hepatitis C viruses, the main pathogens causing chronic liver disease. The major milestones along the discovery of RNAi will also be covered.

Original languageEnglish
Pages (from-to)526-531
Number of pages6
JournalLiver International
Volume24
Issue number6
DOIs
StatePublished - Dec 2004
Externally publishedYes

Keywords

  • Gene therapy
  • RNA interference (RNAi)
  • Viral hepatitis

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