RNA inhibition highlights Cyclin D1 as a potential therapeutic target for mantle cell lymphoma

Shiri Weinstein, Rafi Emmanuel, Ashley M. Jacobi, Avigdor Abraham, Mark A. Behlke, Andrew G. Sprague, Tatiana I. Novobrantseva, Arnon Nagler, Dan Peer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Mantle cell lymphoma is characterized by a genetic translocation results in aberrant overexpression of the CCND1 gene, which encodes cyclin D1. This protein functions as a regulator of the cell cycle progression, hence is considered to play an important role in the pathogenesis of the disease. In this study, we used RNA interference strategies to examine whether cyclin D1 might serve as a therapeutic target for mantle cell lymphoma. Knocking down cyclin D1 resulted in significant growth retardation, cell cycle arrest, and most importantly, induction of apoptosis. These results mark cyclin D1 as a target for mantle cell lymphoma and emphasize the therapeutic potential hidden in its silencing.

Original languageEnglish
Article numbere43343
JournalPLoS ONE
Volume7
Issue number8
DOIs
StatePublished - 14 Aug 2012

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