TY - JOUR
T1 - RNA folding is unaffected by the nonrandom degenerate codon choice
AU - Nussinov, Ruth
PY - 1982/8/30
Y1 - 1982/8/30
N2 - The frequent suggestion that the nonrandom codon usage is explained by its forming more stable mRNAs is tested in 22 genes. Only the histones, globins, and the rat preproinsulin gene show a correlation between the preferred degenerate codons and the stability of the secondary structure of their mRNAs. However, the examined members from the histone and globin gene families, both among the oldest, in evolutionary sense, eukaryotic genes, have a high GC content (approx. 56% compared to an average of 42% in all eukaryotes) which is reflected in their degenerate codon choice and thus in their more stable folding.
AB - The frequent suggestion that the nonrandom codon usage is explained by its forming more stable mRNAs is tested in 22 genes. Only the histones, globins, and the rat preproinsulin gene show a correlation between the preferred degenerate codons and the stability of the secondary structure of their mRNAs. However, the examined members from the histone and globin gene families, both among the oldest, in evolutionary sense, eukaryotic genes, have a high GC content (approx. 56% compared to an average of 42% in all eukaryotes) which is reflected in their degenerate codon choice and thus in their more stable folding.
KW - Codon choice
KW - Computer simulation
KW - Polynucleotide
KW - Secondary structure
KW - mRNA
UR - http://www.scopus.com/inward/record.url?scp=0020493923&partnerID=8YFLogxK
U2 - 10.1016/0167-4781(82)90125-7
DO - 10.1016/0167-4781(82)90125-7
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AN - SCOPUS:0020493923
SN - 0167-4781
VL - 698
SP - 111
EP - 115
JO - BBA - Gene Structure and Expression
JF - BBA - Gene Structure and Expression
IS - 2
ER -