Rivastigmine treatment for the prevention of electroconvulsive therapy-induced memory deficits in patients with schizophrenia

Rafael Stryjer, Dana Ophir, Faina Bar, Baruch Spivak, Abraham Weizman, Rael D. Strous

Research output: Contribution to journalArticlepeer-review

Abstract

Electroconvulsive therapy (ECT) is an effective strategy in some treatment-resistant patients with schizophrenia. However, ECT is associated with cognitive adverse effects, most notably, memory loss. This study examined the effects of rivastigmine, a selective central nervous system acetylcholinesterase inhibitor, with benefits on cognition in Alzheimer disease, on memory performance in patients with schizophrenia treated with ECT. Thirty inpatients with Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision schizophrenia treated with ECT were coadministered rivastigmine (3-4.5 mg/d) or placebo in a prospective, randomized, double-blind, placebo-controlled trial (maximum period of 4 weeks). Over the ECT course, scores on the cognitive subscale of the Alzheimer's Disease Assessment in subjects receiving placebo showed no significant change, whereas subjects receiving rivastigmine displayed decreased cognitive subscale of the Alzheimer's Disease Assessment scores, indicating cognitive improvement (P < 0.05). Findings suggest possible involvement of the acetylcholinergic system in mediation of cognitive deficits after ECT and indicate possible beneficial effects of rivastigmine coadministration in minimizing some of these ECT-induced cognitive impairments.

Original languageEnglish
Pages (from-to)161-164
Number of pages4
JournalClinical Neuropharmacology
Volume35
Issue number4
DOIs
StatePublished - Jul 2012

Keywords

  • ECT
  • rivastigmine
  • schizophrenia

Fingerprint

Dive into the research topics of 'Rivastigmine treatment for the prevention of electroconvulsive therapy-induced memory deficits in patients with schizophrenia'. Together they form a unique fingerprint.

Cite this