Risk of rupture in coronary vulnerable plaques - Fluid-structure interaction studies using patient based Micro-CT and IVUS measurements

Xuan Liang; Suraj Rambhia; Michalis Xenos; Yared Alemu; Natalia Maldonado; Adreanne Kelly; Ifat Lavi; Shmuel Einav; Sheldon Weinbaum; Luis Cardoso; Danny Bluestein

doi:10.1115/SBC2011-53143

Risk of rupture in coronary vulnerable plaques - Fluid-structure interaction studies using patient based Micro-CT and IVUS measurements

Xuan Liang, Suraj Rambhia, Michalis Xenos, Yared Alemu, Natalia Maldonado, Adreanne Kelly, Ifat Lavi, Shmuel Einav, Sheldon Weinbaum, Luis Cardoso, Danny Bluestein

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Fluid-structure interaction (FSI) simulations were conducted in patient-specific coronary vulnerable plaque (VP) geometries reconstructed from Micro-CT and intravascular ultrasound (IVUS), in order to study the effects of microcalcification (micro-Ca), anisotropic vessel properties, and hypertension on plaque vulnerability. The models reconstructed from IVUS included vessel wall, fibrous cap, lipid core and large calcifications. A model reconstructed post mortem from a coronary specimen of a patient with confirmed VP was scanned using high resolution micro-CT. This enabled capture of micro calcifications embedded in the VP fibrous cap in addition to the plaque components mentioned above. Regions susceptible to tissue failure were studied. The thin fibrous cap regions of the plaque were characterized by high stress concentrations. The presence of single or multiple micro-calcified spots embedded within the fibrous cap was studied as well. Micro-Ca significantly enhanced stresses within the fibrous cap, significantly contributing to the risk of rupture.

Original language	English
Title of host publication	ASME 2011 Summer Bioengineering Conference, SBC 2011
Pages	29-30
Number of pages	2
Edition	PARTS A AND B
DOIs	https://doi.org/10.1115/SBC2011-53143
State	Published - 2011
Externally published	Yes
Event	ASME 2011 Summer Bioengineering Conference, SBC 2011 - Farmington, PA, United States Duration: 22 Jun 2011 → 25 Jun 2011

Publication series

Name	ASME 2011 Summer Bioengineering Conference, SBC 2011
Number	PARTS A AND B

Conference

Conference	ASME 2011 Summer Bioengineering Conference, SBC 2011
Country/Territory	United States
City	Farmington, PA
Period	22/06/11 → 25/06/11

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10.1115/SBC2011-53143

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Liang, X., Rambhia, S., Xenos, M., Alemu, Y., Maldonado, N., Kelly, A., Lavi, I., Einav, S., Weinbaum, S., Cardoso, L., & Bluestein, D. (2011). Risk of rupture in coronary vulnerable plaques - Fluid-structure interaction studies using patient based Micro-CT and IVUS measurements. In ASME 2011 Summer Bioengineering Conference, SBC 2011 (PARTS A AND B ed., pp. 29-30). (ASME 2011 Summer Bioengineering Conference, SBC 2011; No. PARTS A AND B). https://doi.org/10.1115/SBC2011-53143

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title = "Risk of rupture in coronary vulnerable plaques - Fluid-structure interaction studies using patient based Micro-CT and IVUS measurements",

abstract = "Fluid-structure interaction (FSI) simulations were conducted in patient-specific coronary vulnerable plaque (VP) geometries reconstructed from Micro-CT and intravascular ultrasound (IVUS), in order to study the effects of microcalcification (micro-Ca), anisotropic vessel properties, and hypertension on plaque vulnerability. The models reconstructed from IVUS included vessel wall, fibrous cap, lipid core and large calcifications. A model reconstructed post mortem from a coronary specimen of a patient with confirmed VP was scanned using high resolution micro-CT. This enabled capture of micro calcifications embedded in the VP fibrous cap in addition to the plaque components mentioned above. Regions susceptible to tissue failure were studied. The thin fibrous cap regions of the plaque were characterized by high stress concentrations. The presence of single or multiple micro-calcified spots embedded within the fibrous cap was studied as well. Micro-Ca significantly enhanced stresses within the fibrous cap, significantly contributing to the risk of rupture.",

author = "Xuan Liang and Suraj Rambhia and Michalis Xenos and Yared Alemu and Natalia Maldonado and Adreanne Kelly and Ifat Lavi and Shmuel Einav and Sheldon Weinbaum and Luis Cardoso and Danny Bluestein",

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Liang, X, Rambhia, S, Xenos, M, Alemu, Y, Maldonado, N, Kelly, A, Lavi, I, Einav, S, Weinbaum, S, Cardoso, L & Bluestein, D 2011, Risk of rupture in coronary vulnerable plaques - Fluid-structure interaction studies using patient based Micro-CT and IVUS measurements. in ASME 2011 Summer Bioengineering Conference, SBC 2011. PARTS A AND B edn, ASME 2011 Summer Bioengineering Conference, SBC 2011, no. PARTS A AND B, pp. 29-30, ASME 2011 Summer Bioengineering Conference, SBC 2011, Farmington, PA, United States, 22/06/11. https://doi.org/10.1115/SBC2011-53143

Risk of rupture in coronary vulnerable plaques - Fluid-structure interaction studies using patient based Micro-CT and IVUS measurements. / Liang, Xuan; Rambhia, Suraj; Xenos, Michalis et al.

ASME 2011 Summer Bioengineering Conference, SBC 2011. PARTS A AND B. ed. 2011. p. 29-30 (ASME 2011 Summer Bioengineering Conference, SBC 2011; No. PARTS A AND B).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Rambhia, Suraj

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AU - Alemu, Yared

AU - Maldonado, Natalia

AU - Kelly, Adreanne

AU - Lavi, Ifat

AU - Einav, Shmuel

AU - Weinbaum, Sheldon

AU - Cardoso, Luis

AU - Bluestein, Danny

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AB - Fluid-structure interaction (FSI) simulations were conducted in patient-specific coronary vulnerable plaque (VP) geometries reconstructed from Micro-CT and intravascular ultrasound (IVUS), in order to study the effects of microcalcification (micro-Ca), anisotropic vessel properties, and hypertension on plaque vulnerability. The models reconstructed from IVUS included vessel wall, fibrous cap, lipid core and large calcifications. A model reconstructed post mortem from a coronary specimen of a patient with confirmed VP was scanned using high resolution micro-CT. This enabled capture of micro calcifications embedded in the VP fibrous cap in addition to the plaque components mentioned above. Regions susceptible to tissue failure were studied. The thin fibrous cap regions of the plaque were characterized by high stress concentrations. The presence of single or multiple micro-calcified spots embedded within the fibrous cap was studied as well. Micro-Ca significantly enhanced stresses within the fibrous cap, significantly contributing to the risk of rupture.

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Liang X, Rambhia S, Xenos M, Alemu Y, Maldonado N, Kelly A et al. Risk of rupture in coronary vulnerable plaques - Fluid-structure interaction studies using patient based Micro-CT and IVUS measurements. In ASME 2011 Summer Bioengineering Conference, SBC 2011. PARTS A AND B ed. 2011. p. 29-30. (ASME 2011 Summer Bioengineering Conference, SBC 2011; PARTS A AND B). doi: 10.1115/SBC2011-53143

Risk of rupture in coronary vulnerable plaques - Fluid-structure interaction studies using patient based Micro-CT and IVUS measurements

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