Risk of rupture in coronary vulnerable plaques - Fluid-structure interaction studies using patient based Micro-CT and IVUS measurements

Xuan Liang, Suraj Rambhia, Michalis Xenos, Yared Alemu, Natalia Maldonado, Adreanne Kelly, Ifat Lavi, Shmuel Einav, Sheldon Weinbaum, Luis Cardoso, Danny Bluestein

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Fluid-structure interaction (FSI) simulations were conducted in patient-specific coronary vulnerable plaque (VP) geometries reconstructed from Micro-CT and intravascular ultrasound (IVUS), in order to study the effects of microcalcification (micro-Ca), anisotropic vessel properties, and hypertension on plaque vulnerability. The models reconstructed from IVUS included vessel wall, fibrous cap, lipid core and large calcifications. A model reconstructed post mortem from a coronary specimen of a patient with confirmed VP was scanned using high resolution micro-CT. This enabled capture of micro calcifications embedded in the VP fibrous cap in addition to the plaque components mentioned above. Regions susceptible to tissue failure were studied. The thin fibrous cap regions of the plaque were characterized by high stress concentrations. The presence of single or multiple micro-calcified spots embedded within the fibrous cap was studied as well. Micro-Ca significantly enhanced stresses within the fibrous cap, significantly contributing to the risk of rupture.

Original languageEnglish
Title of host publicationASME 2011 Summer Bioengineering Conference, SBC 2011
Pages29-30
Number of pages2
EditionPARTS A AND B
DOIs
StatePublished - 2011
Externally publishedYes
EventASME 2011 Summer Bioengineering Conference, SBC 2011 - Farmington, PA, United States
Duration: 22 Jun 201125 Jun 2011

Publication series

NameASME 2011 Summer Bioengineering Conference, SBC 2011
NumberPARTS A AND B

Conference

ConferenceASME 2011 Summer Bioengineering Conference, SBC 2011
Country/TerritoryUnited States
CityFarmington, PA
Period22/06/1125/06/11

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