Risk of metachronous advanced lesions after resection of diminutive and small, non-advanced adenomas

Ido Laish*, Ilia Sergeev, Assaf Stein, Timna Naftali, Fred M. Konikoff

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Background and aims: Current post-polypectomy surveillance interval guidelines do not discriminate between 1–2 diminutive (1–5 mm) and small (6–9 mm) non-advanced adenomas. This study compared the risk for metachronous advanced lesions in these groups. Methods: Patients with 1–2 diminutive, non-advanced adenomas and no further advanced lesions, and patients with no polyps at baseline colonoscopy were retrospectively analyzed to determine the rate of metachronous advanced lesions. These were defined as the combined rate of colon cancer, advanced adenoma and ≥ 3 non-advanced adenomas at surveillance colonoscopy. Polyp size was measured either subjectively by the endoscopist or by pathology-based measurements. Results: Among patients with diminutive (n = 395) and small polyps (n = 110), advanced lesions were found in 68 patients (17.2%) and 16 patients (14.5%), respectively (P = 0.53), during a mean follow-up of 4.3 ± 0.9 years. In contrast, advanced lesions were observed in 33 patients (6.6%) in the no polyp group (n = 505), significantly lower than diminutive (P = 0.000) and small polyp groups (P = 0.002), despite a mean follow-up duration of 6.1 ± 1.9 years. The rate of metachronous advanced lesions was also similar between patients with 1–3 mm polyps (16%) versus 7–9 mm polyps (15.8%). Conclusions: Our findings suggest that among patients who underwent polypectomy of up to 2 non-advanced adenomas, those with diminutive and small polyps have the same risk of metachronous advanced lesions; thus, supporting uniform recommendations for surveillance colonoscopy for these lesions.

Original languageEnglish
Pages (from-to)201-207
Number of pages7
JournalClinics and Research in Hepatology and Gastroenterology
Issue number2
StatePublished - Apr 2019


  • Adenomas
  • Diminutive
  • Metachronous advanced lesions


Dive into the research topics of 'Risk of metachronous advanced lesions after resection of diminutive and small, non-advanced adenomas'. Together they form a unique fingerprint.

Cite this