Risk of infection during adrenocorticotropic hormone treatment in infants with infantile spasms

Raanan Shamir*, Ben Zion Garty, Avinoam Rachmel, Sara Kivity, Gershon Alpert

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


We reviewed the clinical features and laboratory findings of 27 infants with infantile spasms treated with adrenocorticotropic hormone or prednisone during febrile episodes in order to evaluate the incidence of bacteremia, the risk of serious infection, determination of whether serious infections can be identified at presentation and the outcome of febrile episodes. There were 75 febrile episodes including 4 episodes of identified bacteremia (5.3%). Three children who were treated with adrenocorticotropic hormone dosage larger than recommended died. Leukocytosis and a differential count with many immature granulocytes predicted bacteremia in this population. Chest radiography was useful in identifying the cause of fever. The pathogens isolated were similar to those found in this age range. We conclude that the frequency of bacteremia in our patient population is similar to that observed in infants of the same age; however, the outcome is frequently fatal. In addition this increased mortality may be associated with the use of a larger dosage of adrenocorticotropic hormone than recommended.

Original languageEnglish
Pages (from-to)913-916
Number of pages4
JournalPediatric Infectious Disease Journal
Issue number11
StatePublished - Nov 1993


  • Adrenocorticotropic hormone
  • Bacteremia
  • Infantile spasms
  • Infection risk


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