TY - JOUR
T1 - Risk factors for mortality due to Acinetobacter baumannii bacteremia in patients with hematological malignancies–a retrospective study
AU - Shargian-Alon, Liat
AU - Gafter-Gvili, Anat
AU - Ben-Zvi, Haim
AU - Wolach, Ofir
AU - Yeshurun, Moshe
AU - Raanani, Pia
AU - Yahav, Dafna
N1 - Publisher Copyright:
© 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2019/9/19
Y1 - 2019/9/19
N2 - Carbapenem resistant Acinetobacter baumannii (CRAB) is a significant cause of hospital acquired bloodstream infections in patients with hematological malignancies. Data regarding outcomes in this group of patients are limited. We retrospectively analyzed mortality risk factors of hospitalized hematological patients with CRAB bacteremia in our center. Among 46 included patients, overall 7-day mortality was 72% (33/46). Risk factors for 7-day mortality in multivariate analysis were higher infection severity score (SOFA score) at presentation (OR 1.481, 95% CI 1.091–2.012, p =.012) while appropriate antibiotic therapy within 48 h was protective (OR 0.052, 95% CI 0.005–0.590, p =.017). Inappropriate antibiotic therapy within 24 h was not significantly associated with 7-day mortality nor was absolute neutrophil count. Thirty-day mortality was 96% (44/46). CRAB bacteremia in hematological patients is associated with extremely high mortality, regardless of therapy. Infection control measures and antimicrobial stewardship aiming to prevent this infection of dismal prognosis are of major importance.
AB - Carbapenem resistant Acinetobacter baumannii (CRAB) is a significant cause of hospital acquired bloodstream infections in patients with hematological malignancies. Data regarding outcomes in this group of patients are limited. We retrospectively analyzed mortality risk factors of hospitalized hematological patients with CRAB bacteremia in our center. Among 46 included patients, overall 7-day mortality was 72% (33/46). Risk factors for 7-day mortality in multivariate analysis were higher infection severity score (SOFA score) at presentation (OR 1.481, 95% CI 1.091–2.012, p =.012) while appropriate antibiotic therapy within 48 h was protective (OR 0.052, 95% CI 0.005–0.590, p =.017). Inappropriate antibiotic therapy within 24 h was not significantly associated with 7-day mortality nor was absolute neutrophil count. Thirty-day mortality was 96% (44/46). CRAB bacteremia in hematological patients is associated with extremely high mortality, regardless of therapy. Infection control measures and antimicrobial stewardship aiming to prevent this infection of dismal prognosis are of major importance.
KW - Acinetobacter baumannii
KW - bloodstream infection
KW - mortality
UR - http://www.scopus.com/inward/record.url?scp=85064737400&partnerID=8YFLogxK
U2 - 10.1080/10428194.2019.1599113
DO - 10.1080/10428194.2019.1599113
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C2 - 31014145
AN - SCOPUS:85064737400
SN - 1042-8194
VL - 60
SP - 2787
EP - 2792
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 11
ER -