Risk factors for future development of systemic lupus erythematosus in children with idiopathic thrombocytopenic purpura

Rawi Hazzan, Mashaand Mukamel, Joanne Yacobovich, Isaac Yaniv, Hannah Tamary*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

The risk of later development of systemic lupus erythematosus (SLE) in childhood idiopathic thrombocytopenic purpura (ITP) is currently unknown. We retrospectively evaluated the incidence and risk factors of this complication in 222 children with ITP who were followed for a mean of 4.2 ± 4.9 years. During that time 3.6% of the children (8/222) developed SLE; all were females with positive anti-nuclear antibody (ANA), older (12.7 ± 3.6 vs. 6.4 ± 4.3 years old; P < 0.01), and were more likely to have chronic ITP (87.5 vs. 46%; P = 0.02), and had high titers of ANA. The majority of children with ITP who had a positive ANA (14/22, 64%) did not develop SLE.

Original languageEnglish
Pages (from-to)657-659
Number of pages3
JournalPediatric Blood and Cancer
Volume47
Issue number5 SUPPL.
DOIs
StatePublished - 15 Oct 2006

Keywords

  • Anti-nuclear antibody
  • Children
  • ITP
  • SLE

Fingerprint

Dive into the research topics of 'Risk factors for future development of systemic lupus erythematosus in children with idiopathic thrombocytopenic purpura'. Together they form a unique fingerprint.

Cite this