Risk factors for future development of systemic lupus erythematosus in children with idiopathic thrombocytopenic purpura

Rawi Hazzan; Mashaand Mukamel; Joanne Yacobovich; Isaac Yaniv; Hannah Tamary

doi:10.1002/pbc.20970

Risk factors for future development of systemic lupus erythematosus in children with idiopathic thrombocytopenic purpura

Rawi Hazzan, Mashaand Mukamel, Joanne Yacobovich, Isaac Yaniv, Hannah Tamary^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

45 Scopus citations

Abstract

The risk of later development of systemic lupus erythematosus (SLE) in childhood idiopathic thrombocytopenic purpura (ITP) is currently unknown. We retrospectively evaluated the incidence and risk factors of this complication in 222 children with ITP who were followed for a mean of 4.2 ± 4.9 years. During that time 3.6% of the children (8/222) developed SLE; all were females with positive anti-nuclear antibody (ANA), older (12.7 ± 3.6 vs. 6.4 ± 4.3 years old; P < 0.01), and were more likely to have chronic ITP (87.5 vs. 46%; P = 0.02), and had high titers of ANA. The majority of children with ITP who had a positive ANA (14/22, 64%) did not develop SLE.

Original language	English
Pages (from-to)	657-659
Number of pages	3
Journal	Pediatric Blood and Cancer
Volume	47
Issue number	5 SUPPL.
DOIs	https://doi.org/10.1002/pbc.20970
State	Published - 15 Oct 2006

Keywords

Anti-nuclear antibody
Children
ITP
SLE

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title = "Risk factors for future development of systemic lupus erythematosus in children with idiopathic thrombocytopenic purpura",

abstract = "The risk of later development of systemic lupus erythematosus (SLE) in childhood idiopathic thrombocytopenic purpura (ITP) is currently unknown. We retrospectively evaluated the incidence and risk factors of this complication in 222 children with ITP who were followed for a mean of 4.2 ± 4.9 years. During that time 3.6% of the children (8/222) developed SLE; all were females with positive anti-nuclear antibody (ANA), older (12.7 ± 3.6 vs. 6.4 ± 4.3 years old; P < 0.01), and were more likely to have chronic ITP (87.5 vs. 46%; P = 0.02), and had high titers of ANA. The majority of children with ITP who had a positive ANA (14/22, 64%) did not develop SLE.",

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AU - Hazzan, Rawi

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AU - Yaniv, Isaac

AU - Tamary, Hannah

PY - 2006/10/15

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Risk factors for future development of systemic lupus erythematosus in children with idiopathic thrombocytopenic purpura

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