Risk factors associated with impaired ovarian reserve in young women of reproductive age with Crohn's disease

Yue Zhao, Baili Chen, Yao He, Shenghong Zhang, Yun Qiu, Rui Feng, Hongsheng Yang, Zhirong Zeng, Shomron Ben-Horin, Minhu Chen, Ren Mao*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Background/Aims: Crohn's disease (CD) primarily affects young female adults of reproductive age. Few studies have been conducted on this population's ovarian reserve status. The aim of study was to investigate potential risk factors associated with low ovarian reserve, as reflected by serum anti-Müllerian hormone (AMH) in women of reproductive age with CD. Methods: This was a case-control study. Cases included 87 patients with established CD, and healthy controls were matched by age, height and weight in a 1:1 ratio. Serum AMH levels were measured by enzyme-linked immunosorbent assay. Results: The average serum AMH level was significantly lower in CD patients than in control group (2.47±2.08 ng/mL vs. 3.87±1.96 ng/mL, respectively, P<0.001). Serum AMH levels were comparable between CD patients and control group under 25 years of age (4.41±1.52 ng/mL vs. 3.49±2.10 ng/mL, P=0.06), however, serum AMH levels were significantly lower in CD patients over 25 years of age compared to control group (P<0.05). Multivariable analysis showed that an age greater than 25 (odds ratio [OR], 10.03; 95% confidence interval [CI], 1.90-52.93, P=0.007), active disease state (OR, 27.99; 95% CI, 6.13-127.95, P<0.001) and thalidomide use (OR, 15.66; 95% CI, 2.22-110.65, P=0.006) were independent risk factors associated with low ovarian reserve (serum AMH levels <2 ng/mL) in CD patients. Conclusions: Ovarian reserve is impaired in young women of reproductive age with CD. Age over 25 and an active disease state were both independently associated with low ovarian reserve. Thalidomide use could result in impaired ovarian reserve. (Intest Res 2020;18:200-209).

Original languageEnglish
Article number0103
Pages (from-to)200-209
Number of pages10
JournalIntestinal Research
Volume18
Issue number2
DOIs
StatePublished - 1 Apr 2020

Funding

FundersFunder number
National Natural Science Foundation of China81670607, 81970483, 81270473, 81470821
National Natural Science Foundation of China

    Keywords

    • Anti-Mullerian hormone
    • Crohn disease
    • Ovarian reserve

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