Risk factor proportions in Israeli patients with cervical intraepithelial neoplasia 3 and invasive squamous cell carcinoma

Objective. To assess whether there is a difference in the proportion of known risk factors in Israeli women with cervical intraepithelial neoplasia (CIN) 3 compared with those with cervical squamous cell carcinoma (SCC) to explain the incidence discrepancy between the 2 entities. Materials and Methods. At admission, patients with histologically confirmed CIN 3 and SCC diagnosed between 1996 and 2006 filled out a prestructured questionnaire containing queries regarding the following variables: age, place of birth, origin (place of birth of parents), level of education, age at coitarche, number of partners, marital status, age at first pregnancy, number of pregnancies, number of children, type of contraception used, and smoking. A comparison of the proportion of these risk factors in patients with CIN 3 and SCC was performed. Results. No statistically significant difference between 41 CIN 3 and 69 SCC patients was found with regard to any of the risk factors assessed. CONCLUSION. The discrepancy between the frequency of CIN 3 and SCC in Israeli women cannot be explained by a difference in the proportion of the known risk factors.