Rise in serum enzymes induced by hemodialysis

U. Gafter, J. Kraut, J. H. Shinaberger

Research output: Contribution to journalArticlepeer-review


We studied the change in serum enzymes that occurs during a single hemodialysis. In a retrospective analysis, a significant rise in LDH, SGOT, and ALK PH levels was noted in uremic as well as non-uremic patients being dialyzed for severe psoriasis. Sham dialysis (blood not entering the dialyzer) in the latter group caused a rise only in ALK PH. In a prospective study in uremics undergoing acetate hemodialysis with a cellophane-based membrane, we noted a rise in SGOT and ALK PH levels when abnormal pre- and post-dialysis pairs of enzymes were excluded from analysis. This phenomenon also occurred when bicarbonate was substituted for acetate in the bath, or a polyacrylonitrile membrane for a cellophane-based one in the dialyzer. We conclude that a rise in SGOT and ALK PH levels occurs following dialysis and probably represents occult organ dysfunction occurring during the procedure.

Original languageEnglish
Pages (from-to)652-660
Number of pages9
JournalDialysis and Transplantation
Issue number9
StatePublished - 1983
Externally publishedYes


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